Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway

Abstract Colorectal cancer (CRC) is one of the most well-known malignancies with high prevalence and poor 5-year survival. Previous studies have demonstrated that a high-fat diet (HFD) is capable of increasing the odds of developing CRC. Acrolein, an IARC group 2A carcinogen, can be formed from carb...

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Autores principales: Hong-Chieh Tsai, Han-Hsing Tsou, Chun-Chi Lin, Shao-Chen Chen, Hsiao-Wei Cheng, Tsung-Yun Liu, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang, Hao-Wei Teng, Hsiang-Tsai Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5177caa898a641d98b6a15973fb91965
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