Oncolytic virus-derived type I interferon restricts CAR T cell therapy

Oncolytic viruses promote an inflammatory response and elicit anti-tumor immunity. Here the authors show, unexpectedly, that the oncolytic virus, VSVIFNβ, induces type I interferon responses that, when combined with chimeric antigen receptor (CAR) T therapy, lead to the attrition of both CAR T and c...

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Autores principales:	Laura Evgin, Amanda L. Huff, Phonphimon Wongthida, Jill Thompson, Tim Kottke, Jason Tonne, Matthew Schuelke, Katayoun Ayasoufi, Christopher B. Driscoll, Kevin G. Shim, Pierce Reynolds, Dileep D. Monie, Aaron J. Johnson, Matt Coffey, Sarah L. Young, Gary Archer, John Sampson, Jose Pulido, Luis Sanchez Perez, Richard Vile
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5178c922fdee4c4491424f98809482c4
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spelling	oai:doaj.org-article:5178c922fdee4c4491424f98809482c42021-12-02T18:02:42ZOncolytic virus-derived type I interferon restricts CAR T cell therapy10.1038/s41467-020-17011-z2041-1723https://doaj.org/article/5178c922fdee4c4491424f98809482c42020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17011-zhttps://doaj.org/toc/2041-1723Oncolytic viruses promote an inflammatory response and elicit anti-tumor immunity. Here the authors show, unexpectedly, that the oncolytic virus, VSVIFNβ, induces type I interferon responses that, when combined with chimeric antigen receptor (CAR) T therapy, lead to the attrition of both CAR T and conventional T cells, thus dampening their anti-tumor activity.Laura EvginAmanda L. HuffPhonphimon WongthidaJill ThompsonTim KottkeJason TonneMatthew SchuelkeKatayoun AyasoufiChristopher B. DriscollKevin G. ShimPierce ReynoldsDileep D. MonieAaron J. JohnsonMatt CoffeySarah L. YoungGary ArcherJohn SampsonJose PulidoLuis Sanchez PerezRichard VileNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Evgin Amanda L. Huff Phonphimon Wongthida Jill Thompson Tim Kottke Jason Tonne Matthew Schuelke Katayoun Ayasoufi Christopher B. Driscoll Kevin G. Shim Pierce Reynolds Dileep D. Monie Aaron J. Johnson Matt Coffey Sarah L. Young Gary Archer John Sampson Jose Pulido Luis Sanchez Perez Richard Vile Oncolytic virus-derived type I interferon restricts CAR T cell therapy
description	Oncolytic viruses promote an inflammatory response and elicit anti-tumor immunity. Here the authors show, unexpectedly, that the oncolytic virus, VSVIFNβ, induces type I interferon responses that, when combined with chimeric antigen receptor (CAR) T therapy, lead to the attrition of both CAR T and conventional T cells, thus dampening their anti-tumor activity.
format	article
author	Laura Evgin Amanda L. Huff Phonphimon Wongthida Jill Thompson Tim Kottke Jason Tonne Matthew Schuelke Katayoun Ayasoufi Christopher B. Driscoll Kevin G. Shim Pierce Reynolds Dileep D. Monie Aaron J. Johnson Matt Coffey Sarah L. Young Gary Archer John Sampson Jose Pulido Luis Sanchez Perez Richard Vile
author_facet	Laura Evgin Amanda L. Huff Phonphimon Wongthida Jill Thompson Tim Kottke Jason Tonne Matthew Schuelke Katayoun Ayasoufi Christopher B. Driscoll Kevin G. Shim Pierce Reynolds Dileep D. Monie Aaron J. Johnson Matt Coffey Sarah L. Young Gary Archer John Sampson Jose Pulido Luis Sanchez Perez Richard Vile
author_sort	Laura Evgin
title	Oncolytic virus-derived type I interferon restricts CAR T cell therapy
title_short	Oncolytic virus-derived type I interferon restricts CAR T cell therapy
title_full	Oncolytic virus-derived type I interferon restricts CAR T cell therapy
title_fullStr	Oncolytic virus-derived type I interferon restricts CAR T cell therapy
title_full_unstemmed	Oncolytic virus-derived type I interferon restricts CAR T cell therapy
title_sort	oncolytic virus-derived type i interferon restricts car t cell therapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5178c922fdee4c4491424f98809482c4
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Oncolytic virus-derived type I interferon restricts CAR T cell therapy

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