Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity
Histone deacetylase 3 (HDAC3) is a regulator of lipid homeostasis in several tissues, however, its role in intestinal lipid metabolism was not yet known. Here the authors study intestine specific HDAC3 knock out mice and report that these animals have increased fatty acid oxidation and undergo remod...
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Nature Portfolio
2019
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oai:doaj.org-article:517f7ab37ce74aff9258c9ede119de9a2021-12-02T16:51:02ZDeletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity10.1038/s41467-019-13180-82041-1723https://doaj.org/article/517f7ab37ce74aff9258c9ede119de9a2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13180-8https://doaj.org/toc/2041-1723Histone deacetylase 3 (HDAC3) is a regulator of lipid homeostasis in several tissues, however, its role in intestinal lipid metabolism was not yet known. Here the authors study intestine specific HDAC3 knock out mice and report that these animals have increased fatty acid oxidation and undergo remodeling of the intestinal epithelial cell lipidome.Mercedes Dávalos-SalasMagdalene K. MontgomeryCamilla M. ReehorstRebecca NightingaleIrvin NgHolly AndertonSheren Al-ObaidiAnalia LesmanaCameron M. ScottPaul IoannidisHina KalraShivakumar KeerthikumarLars TögelAngela RigopoulosSylvia J. GongDavid S. WilliamsPrusoth YoganantharajaKim Bell-AndersonSuresh MathivananYann GibertScott HiebertAndrew M. ScottMatthew J. WattJohn M. MariadasonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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EN |
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Science Q Mercedes Dávalos-Salas Magdalene K. Montgomery Camilla M. Reehorst Rebecca Nightingale Irvin Ng Holly Anderton Sheren Al-Obaidi Analia Lesmana Cameron M. Scott Paul Ioannidis Hina Kalra Shivakumar Keerthikumar Lars Tögel Angela Rigopoulos Sylvia J. Gong David S. Williams Prusoth Yoganantharaja Kim Bell-Anderson Suresh Mathivanan Yann Gibert Scott Hiebert Andrew M. Scott Matthew J. Watt John M. Mariadason Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity |
| description |
Histone deacetylase 3 (HDAC3) is a regulator of lipid homeostasis in several tissues, however, its role in intestinal lipid metabolism was not yet known. Here the authors study intestine specific HDAC3 knock out mice and report that these animals have increased fatty acid oxidation and undergo remodeling of the intestinal epithelial cell lipidome. |
| format |
article |
| author |
Mercedes Dávalos-Salas Magdalene K. Montgomery Camilla M. Reehorst Rebecca Nightingale Irvin Ng Holly Anderton Sheren Al-Obaidi Analia Lesmana Cameron M. Scott Paul Ioannidis Hina Kalra Shivakumar Keerthikumar Lars Tögel Angela Rigopoulos Sylvia J. Gong David S. Williams Prusoth Yoganantharaja Kim Bell-Anderson Suresh Mathivanan Yann Gibert Scott Hiebert Andrew M. Scott Matthew J. Watt John M. Mariadason |
| author_facet |
Mercedes Dávalos-Salas Magdalene K. Montgomery Camilla M. Reehorst Rebecca Nightingale Irvin Ng Holly Anderton Sheren Al-Obaidi Analia Lesmana Cameron M. Scott Paul Ioannidis Hina Kalra Shivakumar Keerthikumar Lars Tögel Angela Rigopoulos Sylvia J. Gong David S. Williams Prusoth Yoganantharaja Kim Bell-Anderson Suresh Mathivanan Yann Gibert Scott Hiebert Andrew M. Scott Matthew J. Watt John M. Mariadason |
| author_sort |
Mercedes Dávalos-Salas |
| title |
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity |
| title_short |
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity |
| title_full |
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity |
| title_fullStr |
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity |
| title_full_unstemmed |
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity |
| title_sort |
deletion of intestinal hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/517f7ab37ce74aff9258c9ede119de9a |
| work_keys_str_mv |
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1718382977295056896 |