Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected into mice, via a mechanism involving suppressio...

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Autores principales:	Do-Kyun Kim, Geethani Bandara, Young-Eun Cho, Hirsh D. Komarow, Danielle R. Donahue, Baktiar Karim, Moon-Chang Baek, Ho Min Kim, Dean D. Metcalfe, Ana Olivera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5187de6573944f56922f41e7869f5c9c
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spelling	oai:doaj.org-article:5187de6573944f56922f41e7869f5c9c2021-12-02T15:37:56ZMastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation10.1038/s41467-021-22754-42041-1723https://doaj.org/article/5187de6573944f56922f41e7869f5c9c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22754-4https://doaj.org/toc/2041-1723Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected into mice, via a mechanism involving suppression of osteogenic factors via miRNA-30a and miRNA-23a.Do-Kyun KimGeethani BandaraYoung-Eun ChoHirsh D. KomarowDanielle R. DonahueBaktiar KarimMoon-Chang BaekHo Min KimDean D. MetcalfeAna OliveraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Do-Kyun Kim Geethani Bandara Young-Eun Cho Hirsh D. Komarow Danielle R. Donahue Baktiar Karim Moon-Chang Baek Ho Min Kim Dean D. Metcalfe Ana Olivera Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation
description	Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected into mice, via a mechanism involving suppression of osteogenic factors via miRNA-30a and miRNA-23a.
format	article
author	Do-Kyun Kim Geethani Bandara Young-Eun Cho Hirsh D. Komarow Danielle R. Donahue Baktiar Karim Moon-Chang Baek Ho Min Kim Dean D. Metcalfe Ana Olivera
author_facet	Do-Kyun Kim Geethani Bandara Young-Eun Cho Hirsh D. Komarow Danielle R. Donahue Baktiar Karim Moon-Chang Baek Ho Min Kim Dean D. Metcalfe Ana Olivera
author_sort	Do-Kyun Kim
title	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation
title_short	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation
title_full	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation
title_fullStr	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation
title_full_unstemmed	Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation
title_sort	mastocytosis-derived extracellular vesicles deliver mir-23a and mir-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5187de6573944f56922f41e7869f5c9c
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Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

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