Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy

Long Lu,1 Chuanbin Zhang,1 Bingfang Zou,1,2 Yongqiang Wang1 1Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng 475004, People’s Republic of China; 2School of Physics and Electronics, Henan University, Kaifeng 475004, People’s...

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Autores principales:	Lu L, Zhang C, Zou B, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	template prussian blue hollow nanospheres chemotherapy photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5188265fb269498e899248ad778b18a9
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spelling	oai:doaj.org-article:5188265fb269498e899248ad778b18a92021-12-02T08:48:19ZHollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy1178-2013https://doaj.org/article/5188265fb269498e899248ad778b18a92020-07-01T00:00:00Zhttps://www.dovepress.com/hollow-prussian-blue-nanospheres-for-photothermalchemo-synergistic-the-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Long Lu,1 Chuanbin Zhang,1 Bingfang Zou,1,2 Yongqiang Wang1 1Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng 475004, People’s Republic of China; 2School of Physics and Electronics, Henan University, Kaifeng 475004, People’s Republic of ChinaCorrespondence: Yongqiang Wang Email wangyq@henu.edu.cnBackground: The integration of NIR photothermal therapy and chemotherapy is considered as a promising technique for future cancer therapy. Hollow Prussian nanospheres have attracted much attention due to excellent near-infrared photothermal conversion effect and drug-loading capability within an empty cavity. However, to date, the hollow Prussian nanospheres have been prepared by a complex procedure or in organic media, and their shell thickness and size cannot be controlled. Thus, a simple and controllable route is highly desirable to synthesize hollow Prussian nanospheres with controllable parameters.Materials and Methods: Here, in our designed synthesis route, the traditional FeCl3 precursor was replaced with Fe2O3 nanospheres, and then the Prussian blue (PB) nanoparticles were engineered into hollow-structured PB (HPB) nanospheres through an interface reaction, where the Fe2O3 colloidal template provides Fe3+ ions. The reaction mechanism and control factors of HPB nanospheres were systematically investigated. Both in vitro and in vivo biological effects of the as-synthesized HPB nanospheres were evaluated in detail.Results: Through systematical experiments, a solvent-mediated interface reaction mechanism was put forward, and the parameters of HPB nanospheres could be easily adjusted by growth time and template size under optimal water and ethanol ratio. The in vitro tests show the rapid and remarkable photothermal effects of the as-prepared HPB nanospheres under NIR laser irradiation (808 nm). Meanwhile, HPB nanospheres also demonstrated a high DOX loading capacity of 440 mg g− 1 as a drug carrier, and the release of the drug can be regulated by the heat from PB shell under the exposure of an NIR laser. The in vivo experiments confirmed the outstanding performance of HPB nanospheres in photothermal/chemo-synergistic therapy of cancer.Conclusion: A solvent-mediated template route was developed to synthesize hollow Prussian blue (HPB) nanospheres in a simple and controllable way. The in vitro and in vivo results demonstrate the as-synthesized HPB nanospheres as a promising candidate due to their low toxicity and high efficiency for cancer therapy.Keywords: template, Prussian blue, hollow nanospheres, chemotherapy, photothermal therapyLu LZhang CZou BWang YDove Medical Pressarticletemplateprussian bluehollow nanosphereschemotherapyphotothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 5165-5177 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	template prussian blue hollow nanospheres chemotherapy photothermal therapy Medicine (General) R5-920
spellingShingle	template prussian blue hollow nanospheres chemotherapy photothermal therapy Medicine (General) R5-920 Lu L Zhang C Zou B Wang Y Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy
description	Long Lu,1 Chuanbin Zhang,1 Bingfang Zou,1,2 Yongqiang Wang1 1Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng 475004, People’s Republic of China; 2School of Physics and Electronics, Henan University, Kaifeng 475004, People’s Republic of ChinaCorrespondence: Yongqiang Wang Email wangyq@henu.edu.cnBackground: The integration of NIR photothermal therapy and chemotherapy is considered as a promising technique for future cancer therapy. Hollow Prussian nanospheres have attracted much attention due to excellent near-infrared photothermal conversion effect and drug-loading capability within an empty cavity. However, to date, the hollow Prussian nanospheres have been prepared by a complex procedure or in organic media, and their shell thickness and size cannot be controlled. Thus, a simple and controllable route is highly desirable to synthesize hollow Prussian nanospheres with controllable parameters.Materials and Methods: Here, in our designed synthesis route, the traditional FeCl3 precursor was replaced with Fe2O3 nanospheres, and then the Prussian blue (PB) nanoparticles were engineered into hollow-structured PB (HPB) nanospheres through an interface reaction, where the Fe2O3 colloidal template provides Fe3+ ions. The reaction mechanism and control factors of HPB nanospheres were systematically investigated. Both in vitro and in vivo biological effects of the as-synthesized HPB nanospheres were evaluated in detail.Results: Through systematical experiments, a solvent-mediated interface reaction mechanism was put forward, and the parameters of HPB nanospheres could be easily adjusted by growth time and template size under optimal water and ethanol ratio. The in vitro tests show the rapid and remarkable photothermal effects of the as-prepared HPB nanospheres under NIR laser irradiation (808 nm). Meanwhile, HPB nanospheres also demonstrated a high DOX loading capacity of 440 mg g− 1 as a drug carrier, and the release of the drug can be regulated by the heat from PB shell under the exposure of an NIR laser. The in vivo experiments confirmed the outstanding performance of HPB nanospheres in photothermal/chemo-synergistic therapy of cancer.Conclusion: A solvent-mediated template route was developed to synthesize hollow Prussian blue (HPB) nanospheres in a simple and controllable way. The in vitro and in vivo results demonstrate the as-synthesized HPB nanospheres as a promising candidate due to their low toxicity and high efficiency for cancer therapy.Keywords: template, Prussian blue, hollow nanospheres, chemotherapy, photothermal therapy
format	article
author	Lu L Zhang C Zou B Wang Y
author_facet	Lu L Zhang C Zou B Wang Y
author_sort	Lu L
title	Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy
title_short	Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy
title_full	Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy
title_fullStr	Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy
title_full_unstemmed	Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy
title_sort	hollow prussian blue nanospheres for photothermal/chemo-synergistic therapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5188265fb269498e899248ad778b18a9
work_keys_str_mv	AT lul hollowprussianbluenanospheresforphotothermalchemosynergistictherapy AT zhangc hollowprussianbluenanospheresforphotothermalchemosynergistictherapy AT zoub hollowprussianbluenanospheresforphotothermalchemosynergistictherapy AT wangy hollowprussianbluenanospheresforphotothermalchemosynergistictherapy
_version_	1718398360810946560

Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy

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