Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

<h4>Background and aims</h4>Nitric oxide-independent soluble guanylyl cyclase (sGC) activators reactivate the haem-oxidized enzyme in vascular diseases. This study was undertaken to investigate the anti-platelet mechanisms of the haem-independent sGC activator BAY 60-2770 in human washed...

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Autores principales: Camila B Mendes-Silverio, Luiz O S Leiria, Rafael P Morganti, Gabriel F Anhê, Sisi Marcondes, Fabíola Z Mónica, Gilberto De Nucci, Edson Antunes
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/518b0629fd4b4823871dcd9188f75a26
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