Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China

Abstract Elevated systemic levels of soluble cluster of differentiation 14 (sCD14) have been associated with gallbladder cancer (GBC), but the association with sCD14 levels within the gallbladder has not been investigated. Here, we evaluated sCD14 in the bile of 41 GBC cases and 117 gallstone contro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Victoria L. Brun, Amanda F. Corbel, Ann W. Hsing, Troy J. Kemp, Alison L. Van Dyke, Allan Hildesheim, Bin Zhu, Yu-Tang Gao, Ligia A. Pinto, Jill Koshiol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/518b12a2fc3d48b9938a3aa25bdab408
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:518b12a2fc3d48b9938a3aa25bdab408
record_format	dspace
spelling	oai:doaj.org-article:518b12a2fc3d48b9938a3aa25bdab4082021-12-02T16:31:50ZSoluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China10.1038/s41598-021-92728-52045-2322https://doaj.org/article/518b12a2fc3d48b9938a3aa25bdab4082021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92728-5https://doaj.org/toc/2045-2322Abstract Elevated systemic levels of soluble cluster of differentiation 14 (sCD14) have been associated with gallbladder cancer (GBC), but the association with sCD14 levels within the gallbladder has not been investigated. Here, we evaluated sCD14 in the bile of 41 GBC cases and 117 gallstone controls with data on 65 bile inflammation markers. We examined the relationship between bile sCD14 levels and GBC using logistic regression and stratified the analysis by stage. We included GBC-associated inflammatory biomarkers in the model to evaluate the influence of local inflammation. Bile sCD14 levels (third versus first tertile) were associated with GBC (adjusted odds ratio [OR]: 3.0, 95% confidence interval [CI]: 1.2–8.0). The association was equally strong for stage I/II (OR: 3.3, 95% CI: 0.9–15.6) and stage III/IV (OR: 3.2, 95% CI: 1.0–12.4) cancers. Including the GBC-associated inflammatory markers in the model removed the association between bile sCD14 and GBC (OR: 1.0, 95% CI: 0.3–3.5). The findings suggest that immune activation within the gallbladder may be related to GBC development, and the effect of sCD14 is influenced by inflammation. Similar associations across tumor stages suggest that elevated bile sCD14 levels may reflect changes early in GBC pathogenesis. Associations between GBC and sCD14 levels in both bile and plasma suggest sCD14 could be a potential biomarker for GBC.Victoria L. BrunAmanda F. CorbelAnn W. HsingTroy J. KempAlison L. Van DykeAllan HildesheimBin ZhuYu-Tang GaoLigia A. PintoJill KoshiolNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Victoria L. Brun Amanda F. Corbel Ann W. Hsing Troy J. Kemp Alison L. Van Dyke Allan Hildesheim Bin Zhu Yu-Tang Gao Ligia A. Pinto Jill Koshiol Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China
description	Abstract Elevated systemic levels of soluble cluster of differentiation 14 (sCD14) have been associated with gallbladder cancer (GBC), but the association with sCD14 levels within the gallbladder has not been investigated. Here, we evaluated sCD14 in the bile of 41 GBC cases and 117 gallstone controls with data on 65 bile inflammation markers. We examined the relationship between bile sCD14 levels and GBC using logistic regression and stratified the analysis by stage. We included GBC-associated inflammatory biomarkers in the model to evaluate the influence of local inflammation. Bile sCD14 levels (third versus first tertile) were associated with GBC (adjusted odds ratio [OR]: 3.0, 95% confidence interval [CI]: 1.2–8.0). The association was equally strong for stage I/II (OR: 3.3, 95% CI: 0.9–15.6) and stage III/IV (OR: 3.2, 95% CI: 1.0–12.4) cancers. Including the GBC-associated inflammatory markers in the model removed the association between bile sCD14 and GBC (OR: 1.0, 95% CI: 0.3–3.5). The findings suggest that immune activation within the gallbladder may be related to GBC development, and the effect of sCD14 is influenced by inflammation. Similar associations across tumor stages suggest that elevated bile sCD14 levels may reflect changes early in GBC pathogenesis. Associations between GBC and sCD14 levels in both bile and plasma suggest sCD14 could be a potential biomarker for GBC.
format	article
author	Victoria L. Brun Amanda F. Corbel Ann W. Hsing Troy J. Kemp Alison L. Van Dyke Allan Hildesheim Bin Zhu Yu-Tang Gao Ligia A. Pinto Jill Koshiol
author_facet	Victoria L. Brun Amanda F. Corbel Ann W. Hsing Troy J. Kemp Alison L. Van Dyke Allan Hildesheim Bin Zhu Yu-Tang Gao Ligia A. Pinto Jill Koshiol
author_sort	Victoria L. Brun
title	Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China
title_short	Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China
title_full	Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China
title_fullStr	Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China
title_full_unstemmed	Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China
title_sort	soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from shanghai, china
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/518b12a2fc3d48b9938a3aa25bdab408
work_keys_str_mv	AT victorialbrun solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT amandafcorbel solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT annwhsing solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT troyjkemp solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT alisonlvandyke solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT allanhildesheim solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT binzhu solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT yutanggao solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT ligiaapinto solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina AT jillkoshiol solubleclusterofdifferentiation14levelselevatedinbilefromgallbladdercancercasesfromshanghaichina
_version_	1718383871112773632

Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China

Ejemplares similares