Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi

Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles.

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Autores principales: Adriana Adolfi, Valentino M. Gantz, Nijole Jasinskiene, Hsu-Feng Lee, Kristy Hwang, Gerard Terradas, Emily A. Bulger, Arunachalam Ramaiah, Jared B. Bennett, J. J. Emerson, John M. Marshall, Ethan Bier, Anthony A. James
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/518d7f7cbf0f452ca061cd7fb7e5d83b
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spelling oai:doaj.org-article:518d7f7cbf0f452ca061cd7fb7e5d83b2021-12-02T14:41:03ZEfficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi10.1038/s41467-020-19426-02041-1723https://doaj.org/article/518d7f7cbf0f452ca061cd7fb7e5d83b2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19426-0https://doaj.org/toc/2041-1723Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles.Adriana AdolfiValentino M. GantzNijole JasinskieneHsu-Feng LeeKristy HwangGerard TerradasEmily A. BulgerArunachalam RamaiahJared B. BennettJ. J. EmersonJohn M. MarshallEthan BierAnthony A. JamesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Adriana Adolfi
Valentino M. Gantz
Nijole Jasinskiene
Hsu-Feng Lee
Kristy Hwang
Gerard Terradas
Emily A. Bulger
Arunachalam Ramaiah
Jared B. Bennett
J. J. Emerson
John M. Marshall
Ethan Bier
Anthony A. James
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
description Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles.
format article
author Adriana Adolfi
Valentino M. Gantz
Nijole Jasinskiene
Hsu-Feng Lee
Kristy Hwang
Gerard Terradas
Emily A. Bulger
Arunachalam Ramaiah
Jared B. Bennett
J. J. Emerson
John M. Marshall
Ethan Bier
Anthony A. James
author_facet Adriana Adolfi
Valentino M. Gantz
Nijole Jasinskiene
Hsu-Feng Lee
Kristy Hwang
Gerard Terradas
Emily A. Bulger
Arunachalam Ramaiah
Jared B. Bennett
J. J. Emerson
John M. Marshall
Ethan Bier
Anthony A. James
author_sort Adriana Adolfi
title Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
title_short Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
title_full Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
title_fullStr Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
title_full_unstemmed Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
title_sort efficient population modification gene-drive rescue system in the malaria mosquito anopheles stephensi
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/518d7f7cbf0f452ca061cd7fb7e5d83b
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