Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles.
Guardado en:
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/518d7f7cbf0f452ca061cd7fb7e5d83b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:518d7f7cbf0f452ca061cd7fb7e5d83b |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:518d7f7cbf0f452ca061cd7fb7e5d83b2021-12-02T14:41:03ZEfficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi10.1038/s41467-020-19426-02041-1723https://doaj.org/article/518d7f7cbf0f452ca061cd7fb7e5d83b2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19426-0https://doaj.org/toc/2041-1723Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles.Adriana AdolfiValentino M. GantzNijole JasinskieneHsu-Feng LeeKristy HwangGerard TerradasEmily A. BulgerArunachalam RamaiahJared B. BennettJ. J. EmersonJohn M. MarshallEthan BierAnthony A. JamesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Adriana Adolfi Valentino M. Gantz Nijole Jasinskiene Hsu-Feng Lee Kristy Hwang Gerard Terradas Emily A. Bulger Arunachalam Ramaiah Jared B. Bennett J. J. Emerson John M. Marshall Ethan Bier Anthony A. James Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi |
description |
Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles. |
format |
article |
author |
Adriana Adolfi Valentino M. Gantz Nijole Jasinskiene Hsu-Feng Lee Kristy Hwang Gerard Terradas Emily A. Bulger Arunachalam Ramaiah Jared B. Bennett J. J. Emerson John M. Marshall Ethan Bier Anthony A. James |
author_facet |
Adriana Adolfi Valentino M. Gantz Nijole Jasinskiene Hsu-Feng Lee Kristy Hwang Gerard Terradas Emily A. Bulger Arunachalam Ramaiah Jared B. Bennett J. J. Emerson John M. Marshall Ethan Bier Anthony A. James |
author_sort |
Adriana Adolfi |
title |
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi |
title_short |
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi |
title_full |
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi |
title_fullStr |
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi |
title_full_unstemmed |
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi |
title_sort |
efficient population modification gene-drive rescue system in the malaria mosquito anopheles stephensi |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/518d7f7cbf0f452ca061cd7fb7e5d83b |
work_keys_str_mv |
AT adrianaadolfi efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT valentinomgantz efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT nijolejasinskiene efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT hsufenglee efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT kristyhwang efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT gerardterradas efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT emilyabulger efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT arunachalamramaiah efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT jaredbbennett efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT jjemerson efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT johnmmarshall efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT ethanbier efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi AT anthonyajames efficientpopulationmodificationgenedriverescuesysteminthemalariamosquitoanophelesstephensi |
_version_ |
1718390051505700864 |