Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole

Abstract Background Ketoconazole, an antifungal agent, adversely affects spermatogenesis in rodents, but knowledge on adverse effects of prolonged administration of ketoconazole on the fertility of male dogs is lacking. A case of reversible infertility with azoospermia in a male American Staffordshi...

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Autores principales:	Anna Domosławska, Sławomir Zduńczyk
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Testosterone Semen quality Skin lesions Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/518dee140be34591a3adfee32948732c
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spelling	oai:doaj.org-article:518dee140be34591a3adfee32948732c2021-11-28T12:29:20ZReversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole10.1186/s13028-021-00616-91751-0147https://doaj.org/article/518dee140be34591a3adfee32948732c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13028-021-00616-9https://doaj.org/toc/1751-0147Abstract Background Ketoconazole, an antifungal agent, adversely affects spermatogenesis in rodents, but knowledge on adverse effects of prolonged administration of ketoconazole on the fertility of male dogs is lacking. A case of reversible infertility with azoospermia in a male American Staffordshire terrier treated with ketoconazole is reported here. Case presentation A seven-year old male American Staffordshire terrier treated for 3 months with ketoconazole for a persistent Malassezia dermatitis displayed reduced libido and mating of 3 bitches had been unsuccessful. The dog was presented at the clinic 40 days after the treatment had been stopped. At first presentation, low libido and complete absence of sperm in the ejaculate (azoospermia) associated with low testosterone level were found. Repeated examinations revealed that sperm quality and testosterone level had restored 100 days after ketoconazole had been withdrawn. Thereafter, the dog successfully mated 2 bitches. Conclusion The treatment with ketoconazole for 3 months may have led to reversible infertility characterized by azoospermia. Therefore, owners of stud dogs should be informed of this risk prior to initiating such treatment and in case of infertility, previous treatment with ketoconazole should be considered as a possible cause.Anna DomosławskaSławomir ZduńczykBMCarticleTestosteroneSemen qualitySkin lesionsVeterinary medicineSF600-1100ENActa Veterinaria Scandinavica, Vol 63, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Testosterone Semen quality Skin lesions Veterinary medicine SF600-1100
spellingShingle	Testosterone Semen quality Skin lesions Veterinary medicine SF600-1100 Anna Domosławska Sławomir Zduńczyk Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole
description	Abstract Background Ketoconazole, an antifungal agent, adversely affects spermatogenesis in rodents, but knowledge on adverse effects of prolonged administration of ketoconazole on the fertility of male dogs is lacking. A case of reversible infertility with azoospermia in a male American Staffordshire terrier treated with ketoconazole is reported here. Case presentation A seven-year old male American Staffordshire terrier treated for 3 months with ketoconazole for a persistent Malassezia dermatitis displayed reduced libido and mating of 3 bitches had been unsuccessful. The dog was presented at the clinic 40 days after the treatment had been stopped. At first presentation, low libido and complete absence of sperm in the ejaculate (azoospermia) associated with low testosterone level were found. Repeated examinations revealed that sperm quality and testosterone level had restored 100 days after ketoconazole had been withdrawn. Thereafter, the dog successfully mated 2 bitches. Conclusion The treatment with ketoconazole for 3 months may have led to reversible infertility characterized by azoospermia. Therefore, owners of stud dogs should be informed of this risk prior to initiating such treatment and in case of infertility, previous treatment with ketoconazole should be considered as a possible cause.
format	article
author	Anna Domosławska Sławomir Zduńczyk
author_facet	Anna Domosławska Sławomir Zduńczyk
author_sort	Anna Domosławska
title	Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole
title_short	Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole
title_full	Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole
title_fullStr	Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole
title_full_unstemmed	Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole
title_sort	reversible infertility in male dog following prolonged treatment of malassezia dermatitis with ketoconazole
publisher	BMC
publishDate	2021
url	https://doaj.org/article/518dee140be34591a3adfee32948732c
work_keys_str_mv	AT annadomosławska reversibleinfertilityinmaledogfollowingprolongedtreatmentofmalasseziadermatitiswithketoconazole AT sławomirzdunczyk reversibleinfertilityinmaledogfollowingprolongedtreatmentofmalasseziadermatitiswithketoconazole
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Reversible infertility in male dog following prolonged treatment of Malassezia dermatitis with ketoconazole

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