Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.

<h4>Background</h4>Several studies evaluated the associations of tumor necrosis factor-α (TNF-α) polymorphisms with pneumonia in different populations. However, the results were conflicting and controversial.<h4>Methods</h4>Databases including PubMed, Embase, Web of Science,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li Li, Wei Nie, Weifeng Li, Weifeng Yuan, Wenjie Huang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/518e4d8e12d046fda4af4459ef45a892
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:518e4d8e12d046fda4af4459ef45a892
record_format	dspace
spelling	oai:doaj.org-article:518e4d8e12d046fda4af4459ef45a8922021-11-18T07:50:18ZAssociations between TNF-α polymorphisms and pneumonia: a meta-analysis.1932-620310.1371/journal.pone.0061039https://doaj.org/article/518e4d8e12d046fda4af4459ef45a8922013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577187/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Several studies evaluated the associations of tumor necrosis factor-α (TNF-α) polymorphisms with pneumonia in different populations. However, the results were conflicting and controversial.<h4>Methods</h4>Databases including PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Data were extracted independently by two investigators. Crude odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated.<h4>Results</h4>Twelve case-control studies and one cohort study were included. Overall, no association between TNF-α -308A/G polymorphism and pneumonia risk was observed for AA +AG vs. GG (OR = 1.13; 95% CI 0.99-1.30; P = 0.07). In addition, TNF-α -308A/G polymorphism was not associated with pneumonia mortality (OR = 1.96; 95% CI 0.94-4.09; P = 0.07). Furthermore, there was no association of TNF-α -238A/G polymorphism with the risk of pneumonia (OR = 1.38; 95% CI 0.84-2.28; P = 0.20).<h4>Conclusions</h4>TNF-α -308A/G, -238A/G polymorphisms were not associated with pneumonia risk. Moreover, TNF-α -308A/G polymorphism did not play a role in the pneumonia mortality risk.Li LiWei NieWeifeng LiWeifeng YuanWenjie HuangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61039 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Li Wei Nie Weifeng Li Weifeng Yuan Wenjie Huang Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.
description	<h4>Background</h4>Several studies evaluated the associations of tumor necrosis factor-α (TNF-α) polymorphisms with pneumonia in different populations. However, the results were conflicting and controversial.<h4>Methods</h4>Databases including PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Data were extracted independently by two investigators. Crude odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated.<h4>Results</h4>Twelve case-control studies and one cohort study were included. Overall, no association between TNF-α -308A/G polymorphism and pneumonia risk was observed for AA +AG vs. GG (OR = 1.13; 95% CI 0.99-1.30; P = 0.07). In addition, TNF-α -308A/G polymorphism was not associated with pneumonia mortality (OR = 1.96; 95% CI 0.94-4.09; P = 0.07). Furthermore, there was no association of TNF-α -238A/G polymorphism with the risk of pneumonia (OR = 1.38; 95% CI 0.84-2.28; P = 0.20).<h4>Conclusions</h4>TNF-α -308A/G, -238A/G polymorphisms were not associated with pneumonia risk. Moreover, TNF-α -308A/G polymorphism did not play a role in the pneumonia mortality risk.
format	article
author	Li Li Wei Nie Weifeng Li Weifeng Yuan Wenjie Huang
author_facet	Li Li Wei Nie Weifeng Li Weifeng Yuan Wenjie Huang
author_sort	Li Li
title	Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.
title_short	Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.
title_full	Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.
title_fullStr	Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.
title_full_unstemmed	Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.
title_sort	associations between tnf-α polymorphisms and pneumonia: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/518e4d8e12d046fda4af4459ef45a892
work_keys_str_mv	AT lili associationsbetweentnfapolymorphismsandpneumoniaametaanalysis AT weinie associationsbetweentnfapolymorphismsandpneumoniaametaanalysis AT weifengli associationsbetweentnfapolymorphismsandpneumoniaametaanalysis AT weifengyuan associationsbetweentnfapolymorphismsandpneumoniaametaanalysis AT wenjiehuang associationsbetweentnfapolymorphismsandpneumoniaametaanalysis
_version_	1718422850820374528

Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.

Ejemplares similares