Clonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.

In France, the use of the 7-valent pneumococcal conjugate vaccine (PCV7) lead to an overall significant decrease in PCV7 invasive pneumococcal disease (IPD) incidence. However, the decrease in vaccine serotype prevalence was partially counterbalanced by the serotype replacement phenomenon. In this s...

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Autores principales:	Claire Janoir, Robert Cohen, Corinne Levy, Edouard Bingen, Agnès Lepoutre, Laurent Gutmann, Emmanuelle Varon, Observatoires Régionaux du Pneumocoque (ORP) network
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51909e8a45ff4d88b6de997dacd46047
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spelling	oai:doaj.org-article:51909e8a45ff4d88b6de997dacd460472021-11-18T08:29:22ZClonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.1932-620310.1371/journal.pone.0090935https://doaj.org/article/51909e8a45ff4d88b6de997dacd460472014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24603763/?tool=EBIhttps://doaj.org/toc/1932-6203In France, the use of the 7-valent pneumococcal conjugate vaccine (PCV7) lead to an overall significant decrease in PCV7 invasive pneumococcal disease (IPD) incidence. However, the decrease in vaccine serotype prevalence was partially counterbalanced by the serotype replacement phenomenon. In this study, we analyzed the role of the newly described serotype 6C as one of the replacement serotypes. This work was conducted on a large time scale from the early PCV7 era (2002-2003) to the PCV13 era (2010-2011), both on IPD strains recovered from the whole population and nasopharyngeal colonizing strains isolated in infant less than two years, who are known to be the main reservoir for pneumococci. Serotype 6C took advantage over 6A and 6B serotypes, which both decreased over time. A continuous and significant increase in 6C IPD was observed in adults along the study period; in contrast, in children less than two years, only an increase in 6C nasopharyngeal carriage was found, the prevalence of serotype 6C in IPD remaining very low over time. Among 101 6C invasive and colonizing strains studied by MLST, 24 STs were found to be related to three major clonal complexes, CC395, CC176, and CC315. STs related to CC176 tend to disappear after 2009 and were essentially replaced by ST386 (CC315), which dramatically increased over time. This clonal expansion may be explained by the erythromycin and tetracycline resistances associated with this clone. Finally, the decrease observed in nasopharyngeal 6C carriage since 2010, likely related to the PCV13 introduction in the French immunization schedule, is expected to lead to a decrease in 6C IPD in adults thereafter.Claire JanoirRobert CohenCorinne LevyEdouard BingenAgnès LepoutreLaurent GutmannEmmanuelle VaronObservatoires Régionaux du Pneumocoque (ORP) networkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90935 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claire Janoir Robert Cohen Corinne Levy Edouard Bingen Agnès Lepoutre Laurent Gutmann Emmanuelle Varon Observatoires Régionaux du Pneumocoque (ORP) network Clonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.
description	In France, the use of the 7-valent pneumococcal conjugate vaccine (PCV7) lead to an overall significant decrease in PCV7 invasive pneumococcal disease (IPD) incidence. However, the decrease in vaccine serotype prevalence was partially counterbalanced by the serotype replacement phenomenon. In this study, we analyzed the role of the newly described serotype 6C as one of the replacement serotypes. This work was conducted on a large time scale from the early PCV7 era (2002-2003) to the PCV13 era (2010-2011), both on IPD strains recovered from the whole population and nasopharyngeal colonizing strains isolated in infant less than two years, who are known to be the main reservoir for pneumococci. Serotype 6C took advantage over 6A and 6B serotypes, which both decreased over time. A continuous and significant increase in 6C IPD was observed in adults along the study period; in contrast, in children less than two years, only an increase in 6C nasopharyngeal carriage was found, the prevalence of serotype 6C in IPD remaining very low over time. Among 101 6C invasive and colonizing strains studied by MLST, 24 STs were found to be related to three major clonal complexes, CC395, CC176, and CC315. STs related to CC176 tend to disappear after 2009 and were essentially replaced by ST386 (CC315), which dramatically increased over time. This clonal expansion may be explained by the erythromycin and tetracycline resistances associated with this clone. Finally, the decrease observed in nasopharyngeal 6C carriage since 2010, likely related to the PCV13 introduction in the French immunization schedule, is expected to lead to a decrease in 6C IPD in adults thereafter.
format	article
author	Claire Janoir Robert Cohen Corinne Levy Edouard Bingen Agnès Lepoutre Laurent Gutmann Emmanuelle Varon Observatoires Régionaux du Pneumocoque (ORP) network
author_facet	Claire Janoir Robert Cohen Corinne Levy Edouard Bingen Agnès Lepoutre Laurent Gutmann Emmanuelle Varon Observatoires Régionaux du Pneumocoque (ORP) network
author_sort	Claire Janoir
title	Clonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.
title_short	Clonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.
title_full	Clonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.
title_fullStr	Clonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.
title_full_unstemmed	Clonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.
title_sort	clonal expansion of the macrolide resistant st386 within pneumococcal serotype 6c in france.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/51909e8a45ff4d88b6de997dacd46047
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Clonal expansion of the macrolide resistant ST386 within pneumococcal serotype 6C in France.

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