Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface

The O-antigen of LPS is known to limit the binding of antibody to bacterial surface antigens. Here the AUs show that the chemical and physical structure of the O-antigen are central factors in limiting the exposure of surface antigens to antibodies during Salmonella infection, thus defining their pr...

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Autores principales:	C. Coral Domínguez-Medina, Marisol Pérez-Toledo, Anna E. Schager, Jennifer L. Marshall, Charlotte N. Cook, Saeeda Bobat, Hyea Hwang, Byeong Jae Chun, Erin Logan, Jack A. Bryant, Will M. Channell, Faye C. Morris, Sian E. Jossi, Areej Alshayea, Amanda E. Rossiter, Paul A. Barrow, William G. Horsnell, Calman A. MacLennan, Ian R. Henderson, Jeremy H. Lakey, James C. Gumbart, Constantino López-Macías, Vassiliy N. Bavro, Adam F. Cunningham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5196a15dc94f4468af82d42ac9f3cb2e
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spelling	oai:doaj.org-article:5196a15dc94f4468af82d42ac9f3cb2e2021-12-02T14:40:53ZOuter membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface10.1038/s41467-020-14655-92041-1723https://doaj.org/article/5196a15dc94f4468af82d42ac9f3cb2e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14655-9https://doaj.org/toc/2041-1723The O-antigen of LPS is known to limit the binding of antibody to bacterial surface antigens. Here the AUs show that the chemical and physical structure of the O-antigen are central factors in limiting the exposure of surface antigens to antibodies during Salmonella infection, thus defining their protective qualities.C. Coral Domínguez-MedinaMarisol Pérez-ToledoAnna E. SchagerJennifer L. MarshallCharlotte N. CookSaeeda BobatHyea HwangByeong Jae ChunErin LoganJack A. BryantWill M. ChannellFaye C. MorrisSian E. JossiAreej AlshayeaAmanda E. RossiterPaul A. BarrowWilliam G. HorsnellCalman A. MacLennanIan R. HendersonJeremy H. LakeyJames C. GumbartConstantino López-MacíasVassiliy N. BavroAdam F. CunninghamNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q C. Coral Domínguez-Medina Marisol Pérez-Toledo Anna E. Schager Jennifer L. Marshall Charlotte N. Cook Saeeda Bobat Hyea Hwang Byeong Jae Chun Erin Logan Jack A. Bryant Will M. Channell Faye C. Morris Sian E. Jossi Areej Alshayea Amanda E. Rossiter Paul A. Barrow William G. Horsnell Calman A. MacLennan Ian R. Henderson Jeremy H. Lakey James C. Gumbart Constantino López-Macías Vassiliy N. Bavro Adam F. Cunningham Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
description	The O-antigen of LPS is known to limit the binding of antibody to bacterial surface antigens. Here the AUs show that the chemical and physical structure of the O-antigen are central factors in limiting the exposure of surface antigens to antibodies during Salmonella infection, thus defining their protective qualities.
format	article
author	C. Coral Domínguez-Medina Marisol Pérez-Toledo Anna E. Schager Jennifer L. Marshall Charlotte N. Cook Saeeda Bobat Hyea Hwang Byeong Jae Chun Erin Logan Jack A. Bryant Will M. Channell Faye C. Morris Sian E. Jossi Areej Alshayea Amanda E. Rossiter Paul A. Barrow William G. Horsnell Calman A. MacLennan Ian R. Henderson Jeremy H. Lakey James C. Gumbart Constantino López-Macías Vassiliy N. Bavro Adam F. Cunningham
author_facet	C. Coral Domínguez-Medina Marisol Pérez-Toledo Anna E. Schager Jennifer L. Marshall Charlotte N. Cook Saeeda Bobat Hyea Hwang Byeong Jae Chun Erin Logan Jack A. Bryant Will M. Channell Faye C. Morris Sian E. Jossi Areej Alshayea Amanda E. Rossiter Paul A. Barrow William G. Horsnell Calman A. MacLennan Ian R. Henderson Jeremy H. Lakey James C. Gumbart Constantino López-Macías Vassiliy N. Bavro Adam F. Cunningham
author_sort	C. Coral Domínguez-Medina
title	Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
title_short	Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
title_full	Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
title_fullStr	Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
title_full_unstemmed	Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface
title_sort	outer membrane protein size and lps o-antigen define protective antibody targeting to the salmonella surface
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5196a15dc94f4468af82d42ac9f3cb2e
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Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface

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