Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation

S. cerevisiae TBP associated factor 14 (Taf14) is a transcriptional regulator that interacts with multiple nuclear complexes. Here, the authors report that the extra-terminal domain of Taf14 (Taf14ET) recognizes a common motif in various transcriptional coactivator proteins and they solve the NMR st...

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Autores principales:	Guochao Chen, Duo Wang, Bin Wu, Fuxiang Yan, Hongjuan Xue, Quanmeng Wang, Shu Quan, Yong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5199bb852e6d4eb29c3b0d7f59cc8881
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id	oai:doaj.org-article:5199bb852e6d4eb29c3b0d7f59cc8881
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spelling	oai:doaj.org-article:5199bb852e6d4eb29c3b0d7f59cc88812021-12-02T18:01:13ZTaf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation10.1038/s41467-020-18021-72041-1723https://doaj.org/article/5199bb852e6d4eb29c3b0d7f59cc88812020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18021-7https://doaj.org/toc/2041-1723S. cerevisiae TBP associated factor 14 (Taf14) is a transcriptional regulator that interacts with multiple nuclear complexes. Here, the authors report that the extra-terminal domain of Taf14 (Taf14ET) recognizes a common motif in various transcriptional coactivator proteins and they solve the NMR structure of Taf14ET bound the ET-binding motif of Sth1, the catalytic subunit of the RSC (Remodel the Structure of Chromatin) complex, and furthermore show that Taf14ET undergoes liquid-liquid phase separation, which is enhanced by Taf14 interaction partners.Guochao ChenDuo WangBin WuFuxiang YanHongjuan XueQuanmeng WangShu QuanYong ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guochao Chen Duo Wang Bin Wu Fuxiang Yan Hongjuan Xue Quanmeng Wang Shu Quan Yong Chen Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
description	S. cerevisiae TBP associated factor 14 (Taf14) is a transcriptional regulator that interacts with multiple nuclear complexes. Here, the authors report that the extra-terminal domain of Taf14 (Taf14ET) recognizes a common motif in various transcriptional coactivator proteins and they solve the NMR structure of Taf14ET bound the ET-binding motif of Sth1, the catalytic subunit of the RSC (Remodel the Structure of Chromatin) complex, and furthermore show that Taf14ET undergoes liquid-liquid phase separation, which is enhanced by Taf14 interaction partners.
format	article
author	Guochao Chen Duo Wang Bin Wu Fuxiang Yan Hongjuan Xue Quanmeng Wang Shu Quan Yong Chen
author_facet	Guochao Chen Duo Wang Bin Wu Fuxiang Yan Hongjuan Xue Quanmeng Wang Shu Quan Yong Chen
author_sort	Guochao Chen
title	Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
title_short	Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
title_full	Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
title_fullStr	Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
title_full_unstemmed	Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
title_sort	taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5199bb852e6d4eb29c3b0d7f59cc8881
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_version_	1718378987815698432

Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation

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