The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio

Introduction: Smoking is associated with the occurrence and progression of cardiovascular diseases, inflammatory disorders and malignancies. Objective: To study the platelet indices, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in smokers and their correlation with smoking p...

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Autores principales:	Mukta Pujani, Varsha Chauhan, Kanika Singh, Samarth Rastogi, Charu Agarwal, Kamal Gera
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	NLR PLR Mean platelet volume Platelet distribution width Plateletcrit Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/519afdf80c144df782ac60a0dd701808
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spelling	oai:doaj.org-article:519afdf80c144df782ac60a0dd7018082021-11-04T04:37:07ZThe effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio2531-137910.1016/j.htct.2020.07.006https://doaj.org/article/519afdf80c144df782ac60a0dd7018082021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137920301243https://doaj.org/toc/2531-1379Introduction: Smoking is associated with the occurrence and progression of cardiovascular diseases, inflammatory disorders and malignancies. Objective: To study the platelet indices, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in smokers and their correlation with smoking pack-years. Method: A total of 110 smokers and 110 non-smokers were included. The smokers were grouped into three groups: mild (<5 pack-years), moderate (5−10 pack-years) and heavy (>10 pack-years). The platelet count, plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) were noted. The NLR and PLR were calculated and the statistical analysis was made using the Student’s T-test, Analysis of Variance (ANOVA) and Spearman’s correlation coefficient. Results: The platelet count, PCT and PDW were significantly higher with mean values: 218.56 ± 121.31 vs 203.23 ± 80.35 (p-value = 0.038), 0.27 ± 0.10 vs 0.26 ± 0.10 (p-value = 0.041) and 12.54 ± 1.45 vs 11.99 ± 1.70 (p-value = 0.001) in smokers and non-smokers, respectively. The PLR differed significantly with mean values: 119.40 ± 84.81 in smokers and 181.99 ± 313.09 in non-smokers, with a p-value of 0.045. A significant positive correlation was found between pack-years of smoking and platelet count and PLR with the Pearson correlation coefficient of 0.250 and 0.198 and p-values, 0.008 and 0.037, respectively. The Platelet Count, PCT, MPV and PDW varied significantly between mild, moderate and heavy smoker groups, with p-values of 0.045, 0.010, 0.015 and 0.017, respectively. Conclusion: The platelet indices and inflammatory markers NLR and PLR are derived from routine blood investigations, which are easily available and inexpensive. The monitoring of platelet indices, along with the PLR, can be used as early predictors of morbidity in smokers.Mukta PujaniVarsha ChauhanKanika SinghSamarth RastogiCharu AgarwalKamal GeraElsevierarticleNLRPLRMean platelet volumePlatelet distribution widthPlateletcritDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 424-429 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NLR PLR Mean platelet volume Platelet distribution width Plateletcrit Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	NLR PLR Mean platelet volume Platelet distribution width Plateletcrit Diseases of the blood and blood-forming organs RC633-647.5 Mukta Pujani Varsha Chauhan Kanika Singh Samarth Rastogi Charu Agarwal Kamal Gera The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio
description	Introduction: Smoking is associated with the occurrence and progression of cardiovascular diseases, inflammatory disorders and malignancies. Objective: To study the platelet indices, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in smokers and their correlation with smoking pack-years. Method: A total of 110 smokers and 110 non-smokers were included. The smokers were grouped into three groups: mild (<5 pack-years), moderate (5−10 pack-years) and heavy (>10 pack-years). The platelet count, plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) were noted. The NLR and PLR were calculated and the statistical analysis was made using the Student’s T-test, Analysis of Variance (ANOVA) and Spearman’s correlation coefficient. Results: The platelet count, PCT and PDW were significantly higher with mean values: 218.56 ± 121.31 vs 203.23 ± 80.35 (p-value = 0.038), 0.27 ± 0.10 vs 0.26 ± 0.10 (p-value = 0.041) and 12.54 ± 1.45 vs 11.99 ± 1.70 (p-value = 0.001) in smokers and non-smokers, respectively. The PLR differed significantly with mean values: 119.40 ± 84.81 in smokers and 181.99 ± 313.09 in non-smokers, with a p-value of 0.045. A significant positive correlation was found between pack-years of smoking and platelet count and PLR with the Pearson correlation coefficient of 0.250 and 0.198 and p-values, 0.008 and 0.037, respectively. The Platelet Count, PCT, MPV and PDW varied significantly between mild, moderate and heavy smoker groups, with p-values of 0.045, 0.010, 0.015 and 0.017, respectively. Conclusion: The platelet indices and inflammatory markers NLR and PLR are derived from routine blood investigations, which are easily available and inexpensive. The monitoring of platelet indices, along with the PLR, can be used as early predictors of morbidity in smokers.
format	article
author	Mukta Pujani Varsha Chauhan Kanika Singh Samarth Rastogi Charu Agarwal Kamal Gera
author_facet	Mukta Pujani Varsha Chauhan Kanika Singh Samarth Rastogi Charu Agarwal Kamal Gera
author_sort	Mukta Pujani
title	The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio
title_short	The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio
title_full	The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio
title_fullStr	The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio
title_full_unstemmed	The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio
title_sort	effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/519afdf80c144df782ac60a0dd701808
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The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio

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