Large-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights

ABSTRACT Among pathogenic fungi, Candida albicans is most frequently associated with biofilm formation, a lifestyle that is entirely different from the planktonic state. One of the distinguishing features of these biofilms is the presence of extracellular material, commonly referred to as the “biofi...

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Autor principal:	Jose L. Lopez-Ribot
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/519b8678d7f14616bfc8533b8c960ab9
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spelling	oai:doaj.org-article:519b8678d7f14616bfc8533b8c960ab92021-11-15T15:45:55ZLarge-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights10.1128/mBio.01781-142150-7511https://doaj.org/article/519b8678d7f14616bfc8533b8c960ab92014-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01781-14https://doaj.org/toc/2150-7511ABSTRACT Among pathogenic fungi, Candida albicans is most frequently associated with biofilm formation, a lifestyle that is entirely different from the planktonic state. One of the distinguishing features of these biofilms is the presence of extracellular material, commonly referred to as the “biofilm matrix.” The fungal biofilm matrix embeds sessile cells within these communities and plays important structural and physiological functions, including antifungal drug resistance with important clinical repercussions. This matrix is mostly self-produced by the fungal cells themselves and is composed of different types of biopolymers. In C. albicans, the main components of the biofilm matrix are carbohydrates, proteins, lipids, and DNA, but many of them remain unidentified and/or poorly characterized. In their recent article, Zarnowski et al. [mBio 5(4):e01333-14, 2014, doi:10.1128/mBio.01333-14] used a variety of biochemical and state-of-the-art “omic” approaches (glycomics, proteomics, and lipidomics) to identify and characterize unique biopolymers present in the C. albicans biofilm matrix. Besides generating a true “encyclopedic” catalog of individual moieties from each of the different macromolecular categories, results also provide important insights into structural and functional aspects of the fungal biofilm matrix, particularly the interaction between different components and the contribution of multiple matrix constituents to biofilm antifungal drug resistance.Jose L. Lopez-RibotAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 5 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jose L. Lopez-Ribot Large-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights
description	ABSTRACT Among pathogenic fungi, Candida albicans is most frequently associated with biofilm formation, a lifestyle that is entirely different from the planktonic state. One of the distinguishing features of these biofilms is the presence of extracellular material, commonly referred to as the “biofilm matrix.” The fungal biofilm matrix embeds sessile cells within these communities and plays important structural and physiological functions, including antifungal drug resistance with important clinical repercussions. This matrix is mostly self-produced by the fungal cells themselves and is composed of different types of biopolymers. In C. albicans, the main components of the biofilm matrix are carbohydrates, proteins, lipids, and DNA, but many of them remain unidentified and/or poorly characterized. In their recent article, Zarnowski et al. [mBio 5(4):e01333-14, 2014, doi:10.1128/mBio.01333-14] used a variety of biochemical and state-of-the-art “omic” approaches (glycomics, proteomics, and lipidomics) to identify and characterize unique biopolymers present in the C. albicans biofilm matrix. Besides generating a true “encyclopedic” catalog of individual moieties from each of the different macromolecular categories, results also provide important insights into structural and functional aspects of the fungal biofilm matrix, particularly the interaction between different components and the contribution of multiple matrix constituents to biofilm antifungal drug resistance.
format	article
author	Jose L. Lopez-Ribot
author_facet	Jose L. Lopez-Ribot
author_sort	Jose L. Lopez-Ribot
title	Large-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights
title_short	Large-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights
title_full	Large-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights
title_fullStr	Large-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights
title_full_unstemmed	Large-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights
title_sort	large-scale biochemical profiling of the <named-content content-type="genus-species">candida albicans</named-content> biofilm matrix: new compositional, structural, and functional insights
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/519b8678d7f14616bfc8533b8c960ab9
work_keys_str_mv	AT josellopezribot largescalebiochemicalprofilingofthenamedcontentcontenttypegenusspeciescandidaalbicansnamedcontentbiofilmmatrixnewcompositionalstructuralandfunctionalinsights
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Large-Scale Biochemical Profiling of the <named-content content-type="genus-species">Candida albicans</named-content> Biofilm Matrix: New Compositional, Structural, and Functional Insights

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