The Role of Different Inflammatory Indices in the Diagnosis of COVID-19

Marwa Eissa,1,2 Sabry Shaarawy,3 Mona S Abdellateif3 1Internal Medicine and Endocrinology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Endocrinology Department, Faculty of Armed Forces of Medical College (AFMC), Cairo, Egypt; 3Medical Biochemistry and Molecular Biology, Cancer B...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eissa M, Shaarawy S, Abdellateif MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	covid-19 c-reactive protein lymphocytes inflammatory index platelets sii. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/519bfa27538c4869a2083e021ba0af5f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:519bfa27538c4869a2083e021ba0af5f
record_format	dspace
spelling	oai:doaj.org-article:519bfa27538c4869a2083e021ba0af5f2021-11-09T18:40:34ZThe Role of Different Inflammatory Indices in the Diagnosis of COVID-191178-7074https://doaj.org/article/519bfa27538c4869a2083e021ba0af5f2021-11-01T00:00:00Zhttps://www.dovepress.com/the-role-of-different-inflammatory-indices-in-the-diagnosis-of-covid-1-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Marwa Eissa,1,2 Sabry Shaarawy,3 Mona S Abdellateif3 1Internal Medicine and Endocrinology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Endocrinology Department, Faculty of Armed Forces of Medical College (AFMC), Cairo, Egypt; 3Medical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, EgyptCorrespondence: Mona S AbdellateifMedical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, 11976, EgyptFax + 202 23644720Email mona.sayed@nci.cu.edu.egAim: To assess the role of different inflammatory indices in the diagnosis of COVID-19 infection.Methods: The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), derived NLR (dNLR), neutrophil to lymphocyte, platelet ratio (NLPR), systemic inflammation index (SII), aggregate index of systemic inflammation (AISI), systemic inflammation response index (SIRI) and C-reactive protein-to-lymphocyte ratio (CRP/L) were assessed in 88 COVID-19 patients compared to 41 healthy control subjects.Results: The NLR, PLR, NLPR, SIRI, and CRP/L were significantly increased, while LMR was significantly decreased in COVID-19 patients compared to the control group (P = 0.008, 0.011, < 0.001, 0.032, 0.002 and P < 0.001; respectively). The AUC for the assessed indices was LMR (0.738, P = 0.008), NLPR (0.721, P < 0.001), CRP/L (0.692, P = 0.002), NLR (0.649, P < 0.001), PLR (0.643, P = 0.011), SIRI (0.623, P = 0.032), dNLR (0.590, P = 0.111), SII (0.571, P = 0.207), and AISI (0.567, P-0.244). Multivariate analysis showed that NLPR > 0.011 (OR: 38.751, P = 0.014), and CRP/L > 7.6 (OR: 7.604, P = 0.022) are possible independent diagnostic factors for COVID-19 infection.Conclusion: NLPR and CRP/L could be potential independent diagnostic factors for COVID-19 infection.Keywords: COVID-19, C-reactive protein, lymphocytes, inflammatory index, platelets, SIIEissa MShaarawy SAbdellateif MSDove Medical Pressarticlecovid-19c-reactive proteinlymphocytesinflammatory indexplateletssii.Medicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 7843-7853 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 c-reactive protein lymphocytes inflammatory index platelets sii. Medicine (General) R5-920
spellingShingle	covid-19 c-reactive protein lymphocytes inflammatory index platelets sii. Medicine (General) R5-920 Eissa M Shaarawy S Abdellateif MS The Role of Different Inflammatory Indices in the Diagnosis of COVID-19
description	Marwa Eissa,1,2 Sabry Shaarawy,3 Mona S Abdellateif3 1Internal Medicine and Endocrinology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Endocrinology Department, Faculty of Armed Forces of Medical College (AFMC), Cairo, Egypt; 3Medical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, EgyptCorrespondence: Mona S AbdellateifMedical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, 11976, EgyptFax + 202 23644720Email mona.sayed@nci.cu.edu.egAim: To assess the role of different inflammatory indices in the diagnosis of COVID-19 infection.Methods: The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), derived NLR (dNLR), neutrophil to lymphocyte, platelet ratio (NLPR), systemic inflammation index (SII), aggregate index of systemic inflammation (AISI), systemic inflammation response index (SIRI) and C-reactive protein-to-lymphocyte ratio (CRP/L) were assessed in 88 COVID-19 patients compared to 41 healthy control subjects.Results: The NLR, PLR, NLPR, SIRI, and CRP/L were significantly increased, while LMR was significantly decreased in COVID-19 patients compared to the control group (P = 0.008, 0.011, < 0.001, 0.032, 0.002 and P < 0.001; respectively). The AUC for the assessed indices was LMR (0.738, P = 0.008), NLPR (0.721, P < 0.001), CRP/L (0.692, P = 0.002), NLR (0.649, P < 0.001), PLR (0.643, P = 0.011), SIRI (0.623, P = 0.032), dNLR (0.590, P = 0.111), SII (0.571, P = 0.207), and AISI (0.567, P-0.244). Multivariate analysis showed that NLPR > 0.011 (OR: 38.751, P = 0.014), and CRP/L > 7.6 (OR: 7.604, P = 0.022) are possible independent diagnostic factors for COVID-19 infection.Conclusion: NLPR and CRP/L could be potential independent diagnostic factors for COVID-19 infection.Keywords: COVID-19, C-reactive protein, lymphocytes, inflammatory index, platelets, SII
format	article
author	Eissa M Shaarawy S Abdellateif MS
author_facet	Eissa M Shaarawy S Abdellateif MS
author_sort	Eissa M
title	The Role of Different Inflammatory Indices in the Diagnosis of COVID-19
title_short	The Role of Different Inflammatory Indices in the Diagnosis of COVID-19
title_full	The Role of Different Inflammatory Indices in the Diagnosis of COVID-19
title_fullStr	The Role of Different Inflammatory Indices in the Diagnosis of COVID-19
title_full_unstemmed	The Role of Different Inflammatory Indices in the Diagnosis of COVID-19
title_sort	role of different inflammatory indices in the diagnosis of covid-19
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/519bfa27538c4869a2083e021ba0af5f
work_keys_str_mv	AT eissam theroleofdifferentinflammatoryindicesinthediagnosisofcovid19 AT shaarawys theroleofdifferentinflammatoryindicesinthediagnosisofcovid19 AT abdellateifms theroleofdifferentinflammatoryindicesinthediagnosisofcovid19 AT eissam roleofdifferentinflammatoryindicesinthediagnosisofcovid19 AT shaarawys roleofdifferentinflammatoryindicesinthediagnosisofcovid19 AT abdellateifms roleofdifferentinflammatoryindicesinthediagnosisofcovid19
_version_	1718440836362928128

The Role of Different Inflammatory Indices in the Diagnosis of COVID-19

Ejemplares similares