Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences hav...

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Autores principales:	Xiaoyue Jia, Ran Yang, Jiyao Li, Lei Zhao, Xuedong Zhou, Xin Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gut microbiota periodontitis gut-bone axis gut epithelial barrier osteoimmunology alveolar bone loss Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/51a14cc00b854b76a4022dfe5b4c55d4
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spelling	oai:doaj.org-article:51a14cc00b854b76a4022dfe5b4c55d42021-11-16T07:48:37ZGut-Bone Axis: A Non-Negligible Contributor to Periodontitis2235-298810.3389/fcimb.2021.752708https://doaj.org/article/51a14cc00b854b76a4022dfe5b4c55d42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.752708/fullhttps://doaj.org/toc/2235-2988Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organs, contributing to pathological bone loss. Gut microbial translocation also enhances systemic inflammation and induces trained myelopoiesis in the bone marrow, which potentially aggravates periodontitis. Furthermore, gut microbiota possibly affects bone health via regulating the production of hormone or hormone-like substances. In this review, we discussed the links between gut microbiota and periodontitis, with a particular focus on the underlying mechanisms of gut-bone axis by which systemic diseases or local infections contribute to the pathogenesis of periodontitis.Xiaoyue JiaXiaoyue JiaRan YangRan YangJiyao LiJiyao LiLei ZhaoLei ZhaoXuedong ZhouXuedong ZhouXin XuXin XuFrontiers Media S.A.articlegut microbiotaperiodontitisgut-bone axisgut epithelial barrierosteoimmunologyalveolar bone lossMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut microbiota periodontitis gut-bone axis gut epithelial barrier osteoimmunology alveolar bone loss Microbiology QR1-502
spellingShingle	gut microbiota periodontitis gut-bone axis gut epithelial barrier osteoimmunology alveolar bone loss Microbiology QR1-502 Xiaoyue Jia Xiaoyue Jia Ran Yang Ran Yang Jiyao Li Jiyao Li Lei Zhao Lei Zhao Xuedong Zhou Xuedong Zhou Xin Xu Xin Xu Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis
description	Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organs, contributing to pathological bone loss. Gut microbial translocation also enhances systemic inflammation and induces trained myelopoiesis in the bone marrow, which potentially aggravates periodontitis. Furthermore, gut microbiota possibly affects bone health via regulating the production of hormone or hormone-like substances. In this review, we discussed the links between gut microbiota and periodontitis, with a particular focus on the underlying mechanisms of gut-bone axis by which systemic diseases or local infections contribute to the pathogenesis of periodontitis.
format	article
author	Xiaoyue Jia Xiaoyue Jia Ran Yang Ran Yang Jiyao Li Jiyao Li Lei Zhao Lei Zhao Xuedong Zhou Xuedong Zhou Xin Xu Xin Xu
author_facet	Xiaoyue Jia Xiaoyue Jia Ran Yang Ran Yang Jiyao Li Jiyao Li Lei Zhao Lei Zhao Xuedong Zhou Xuedong Zhou Xin Xu Xin Xu
author_sort	Xiaoyue Jia
title	Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis
title_short	Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis
title_full	Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis
title_fullStr	Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis
title_full_unstemmed	Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis
title_sort	gut-bone axis: a non-negligible contributor to periodontitis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/51a14cc00b854b76a4022dfe5b4c55d4
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Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

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