Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection

Transfer of a host’s microbiota by faecal microbiota transplantation has shown benefit in the context of recurrent Clostridioides difficle infection. Here the authors shows the inflammatory status of the recipient can impact on engraftment and the efficacy of the introduced microbiota in a model of...

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Autores principales:	Eric R. Littmann, Jung-Jin Lee, Joshua E. Denny, Zahidul Alam, Jeffrey R. Maslanka, Isma Zarin, Rina Matsuda, Rebecca A. Carter, Bože Susac, Miriam S. Saffern, Bryton Fett, Lisa M. Mattei, Kyle Bittinger, Michael C. Abt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51a2af39bf664b42a1d9030c65912562
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spelling	oai:doaj.org-article:51a2af39bf664b42a1d9030c659125622021-12-02T10:44:18ZHost immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection10.1038/s41467-020-20793-x2041-1723https://doaj.org/article/51a2af39bf664b42a1d9030c659125622021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20793-xhttps://doaj.org/toc/2041-1723Transfer of a host’s microbiota by faecal microbiota transplantation has shown benefit in the context of recurrent Clostridioides difficle infection. Here the authors shows the inflammatory status of the recipient can impact on engraftment and the efficacy of the introduced microbiota in a model of C.difficile infection.Eric R. LittmannJung-Jin LeeJoshua E. DennyZahidul AlamJeffrey R. MaslankaIsma ZarinRina MatsudaRebecca A. CarterBože SusacMiriam S. SaffernBryton FettLisa M. MatteiKyle BittingerMichael C. AbtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eric R. Littmann Jung-Jin Lee Joshua E. Denny Zahidul Alam Jeffrey R. Maslanka Isma Zarin Rina Matsuda Rebecca A. Carter Bože Susac Miriam S. Saffern Bryton Fett Lisa M. Mattei Kyle Bittinger Michael C. Abt Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection
description	Transfer of a host’s microbiota by faecal microbiota transplantation has shown benefit in the context of recurrent Clostridioides difficle infection. Here the authors shows the inflammatory status of the recipient can impact on engraftment and the efficacy of the introduced microbiota in a model of C.difficile infection.
format	article
author	Eric R. Littmann Jung-Jin Lee Joshua E. Denny Zahidul Alam Jeffrey R. Maslanka Isma Zarin Rina Matsuda Rebecca A. Carter Bože Susac Miriam S. Saffern Bryton Fett Lisa M. Mattei Kyle Bittinger Michael C. Abt
author_facet	Eric R. Littmann Jung-Jin Lee Joshua E. Denny Zahidul Alam Jeffrey R. Maslanka Isma Zarin Rina Matsuda Rebecca A. Carter Bože Susac Miriam S. Saffern Bryton Fett Lisa M. Mattei Kyle Bittinger Michael C. Abt
author_sort	Eric R. Littmann
title	Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection
title_short	Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection
title_full	Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection
title_fullStr	Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection
title_full_unstemmed	Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection
title_sort	host immunity modulates the efficacy of microbiota transplantation for treatment of clostridioides difficile infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/51a2af39bf664b42a1d9030c65912562
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Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection

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