Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest

Abstract Several studies have shown that the benefits of working memory (WM) training can be attributed to functional and structural neural changes in the underlying neural substrate. In the current study, we investigated whether the functional connectivity of the brain at rest in the default mode n...

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Main Authors:	Tiina Salminen, Caroline Garcia Forlim, Torsten Schubert, Simone Kühn
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/51a930e5794949c78f5ecf9df6665c8f
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spelling	oai:doaj.org-article:51a930e5794949c78f5ecf9df6665c8f2021-12-02T11:41:56ZDual n-back training improves functional connectivity of the right inferior frontal gyrus at rest10.1038/s41598-020-77310-92045-2322https://doaj.org/article/51a930e5794949c78f5ecf9df6665c8f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77310-9https://doaj.org/toc/2045-2322Abstract Several studies have shown that the benefits of working memory (WM) training can be attributed to functional and structural neural changes in the underlying neural substrate. In the current study, we investigated whether the functional connectivity of the brain at rest in the default mode network (DMN) changes with WM training. We varied the complexity of the training intervention so, that half of the participants attended dual n-back training whereas the other half attended single n-back training. This way we could assess the effects of different training task parameters on possible connectivity changes. After 16 training sessions, the dual n-back training group showed improved performance accompanied by increased functional connectivity of the ventral DMN in the right inferior frontal gyrus, which correlated with improvements in WM. We also observed decreased functional connectivity in the left superior parietal cortex in this group. The single n-back training group did not show significant training-related changes. These results show that a demanding short-term WM training intervention can alter the default state of the brain.Tiina SalminenCaroline Garcia ForlimTorsten SchubertSimone KühnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiina Salminen Caroline Garcia Forlim Torsten Schubert Simone Kühn Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest
description	Abstract Several studies have shown that the benefits of working memory (WM) training can be attributed to functional and structural neural changes in the underlying neural substrate. In the current study, we investigated whether the functional connectivity of the brain at rest in the default mode network (DMN) changes with WM training. We varied the complexity of the training intervention so, that half of the participants attended dual n-back training whereas the other half attended single n-back training. This way we could assess the effects of different training task parameters on possible connectivity changes. After 16 training sessions, the dual n-back training group showed improved performance accompanied by increased functional connectivity of the ventral DMN in the right inferior frontal gyrus, which correlated with improvements in WM. We also observed decreased functional connectivity in the left superior parietal cortex in this group. The single n-back training group did not show significant training-related changes. These results show that a demanding short-term WM training intervention can alter the default state of the brain.
format	article
author	Tiina Salminen Caroline Garcia Forlim Torsten Schubert Simone Kühn
author_facet	Tiina Salminen Caroline Garcia Forlim Torsten Schubert Simone Kühn
author_sort	Tiina Salminen
title	Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest
title_short	Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest
title_full	Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest
title_fullStr	Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest
title_full_unstemmed	Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest
title_sort	dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/51a930e5794949c78f5ecf9df6665c8f
work_keys_str_mv	AT tiinasalminen dualnbacktrainingimprovesfunctionalconnectivityoftherightinferiorfrontalgyrusatrest AT carolinegarciaforlim dualnbacktrainingimprovesfunctionalconnectivityoftherightinferiorfrontalgyrusatrest AT torstenschubert dualnbacktrainingimprovesfunctionalconnectivityoftherightinferiorfrontalgyrusatrest AT simonekuhn dualnbacktrainingimprovesfunctionalconnectivityoftherightinferiorfrontalgyrusatrest
_version_	1718395397737545728

Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest

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