A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis

Abstract Sestrin 2, a highly conserved stress-induced protein, participates in the pathological processes of metabolic and age-related diseases. This p53-inducible protein also regulates cell growth and metabolism, which is closely related to malignant tumorigenesis. Sestrin 2 was reported to regula...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Junsheng Qu, Moyi Luo, Jingwen Zhang, Fang Han, Ningning Hou, Ruiyan Pan, Xiaodong Sun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Sestrin 2 Cancer Tumor suppressor Tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/51ab007e9e01434fbaedeb03b7d8d383
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:51ab007e9e01434fbaedeb03b7d8d383
record_format	dspace
spelling	oai:doaj.org-article:51ab007e9e01434fbaedeb03b7d8d3832021-11-21T12:39:33ZA paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis10.1186/s12935-021-02317-91475-2867https://doaj.org/article/51ab007e9e01434fbaedeb03b7d8d3832021-11-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02317-9https://doaj.org/toc/1475-2867Abstract Sestrin 2, a highly conserved stress-induced protein, participates in the pathological processes of metabolic and age-related diseases. This p53-inducible protein also regulates cell growth and metabolism, which is closely related to malignant tumorigenesis. Sestrin 2 was reported to regulate various cellular processes, such as tumor cell proliferation, invasion and metastasis, apoptosis, anoikis resistance, and drug resistance. Although sestrin 2 is associated with colorectal, lung, liver, and other cancers, sestrin 2 expression varies among different types of cancer, and the effects and mechanisms of action of this protein are also different. Sestrin 2 was considered a tumor suppressor gene in most studies, whereas conflicting reports considered sestrin 2 an oncogene. Thus, this review aims to examine the literature regarding sestrin 2 in various cancers, summarize its roles in suppression and tumorigenesis, discuss potential mechanisms in the regulation of cancer, and provide a basis for follow-up research and potential cancer treatment development.Junsheng QuMoyi LuoJingwen ZhangFang HanNingning HouRuiyan PanXiaodong SunBMCarticleSestrin 2CancerTumor suppressorTumorigenesisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sestrin 2 Cancer Tumor suppressor Tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Sestrin 2 Cancer Tumor suppressor Tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Junsheng Qu Moyi Luo Jingwen Zhang Fang Han Ningning Hou Ruiyan Pan Xiaodong Sun A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
description	Abstract Sestrin 2, a highly conserved stress-induced protein, participates in the pathological processes of metabolic and age-related diseases. This p53-inducible protein also regulates cell growth and metabolism, which is closely related to malignant tumorigenesis. Sestrin 2 was reported to regulate various cellular processes, such as tumor cell proliferation, invasion and metastasis, apoptosis, anoikis resistance, and drug resistance. Although sestrin 2 is associated with colorectal, lung, liver, and other cancers, sestrin 2 expression varies among different types of cancer, and the effects and mechanisms of action of this protein are also different. Sestrin 2 was considered a tumor suppressor gene in most studies, whereas conflicting reports considered sestrin 2 an oncogene. Thus, this review aims to examine the literature regarding sestrin 2 in various cancers, summarize its roles in suppression and tumorigenesis, discuss potential mechanisms in the regulation of cancer, and provide a basis for follow-up research and potential cancer treatment development.
format	article
author	Junsheng Qu Moyi Luo Jingwen Zhang Fang Han Ningning Hou Ruiyan Pan Xiaodong Sun
author_facet	Junsheng Qu Moyi Luo Jingwen Zhang Fang Han Ningning Hou Ruiyan Pan Xiaodong Sun
author_sort	Junsheng Qu
title	A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
title_short	A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
title_full	A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
title_fullStr	A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
title_full_unstemmed	A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
title_sort	paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/51ab007e9e01434fbaedeb03b7d8d383
work_keys_str_mv	AT junshengqu aparadoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT moyiluo aparadoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT jingwenzhang aparadoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT fanghan aparadoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT ningninghou aparadoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT ruiyanpan aparadoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT xiaodongsun aparadoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT junshengqu paradoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT moyiluo paradoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT jingwenzhang paradoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT fanghan paradoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT ningninghou paradoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT ruiyanpan paradoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis AT xiaodongsun paradoxicalroleforsestrin2proteinintumorsuppressionandtumorigenesis
_version_	1718418882223407104

A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis

Ejemplares similares