Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production

Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production

Imidazole propionate (ImP) produced by gut microbiota has been associated with type 2 diabetes. Here, the authors present crystal structures of the ImP biosynthesis enzyme urocanate reductase in four different states, providing molecular insights into its catalytic mechanism.

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Autores principales: Raminta Venskutonytė, Ara Koh, Olof Stenström, Muhammad Tanweer Khan, Annika Lundqvist, Mikael Akke, Fredrik Bäckhed, Karin Lindkvist-Petersson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/51b05c6e4427465ea9174681f26b1d76
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spelling oai:doaj.org-article:51b05c6e4427465ea9174681f26b1d762021-12-02T15:52:56ZStructural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production10.1038/s41467-021-21548-y2041-1723https://doaj.org/article/51b05c6e4427465ea9174681f26b1d762021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21548-yhttps://doaj.org/toc/2041-1723Imidazole propionate (ImP) produced by gut microbiota has been associated with type 2 diabetes. Here, the authors present crystal structures of the ImP biosynthesis enzyme urocanate reductase in four different states, providing molecular insights into its catalytic mechanism.Raminta VenskutonytėAra KohOlof StenströmMuhammad Tanweer KhanAnnika LundqvistMikael AkkeFredrik BäckhedKarin Lindkvist-PeterssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Raminta Venskutonytė
Ara Koh
Olof Stenström
Muhammad Tanweer Khan
Annika Lundqvist
Mikael Akke
Fredrik Bäckhed
Karin Lindkvist-Petersson
Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
description Imidazole propionate (ImP) produced by gut microbiota has been associated with type 2 diabetes. Here, the authors present crystal structures of the ImP biosynthesis enzyme urocanate reductase in four different states, providing molecular insights into its catalytic mechanism.
format article
author Raminta Venskutonytė
Ara Koh
Olof Stenström
Muhammad Tanweer Khan
Annika Lundqvist
Mikael Akke
Fredrik Bäckhed
Karin Lindkvist-Petersson
author_facet Raminta Venskutonytė
Ara Koh
Olof Stenström
Muhammad Tanweer Khan
Annika Lundqvist
Mikael Akke
Fredrik Bäckhed
Karin Lindkvist-Petersson
author_sort Raminta Venskutonytė
title Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_short Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_full Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_fullStr Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_full_unstemmed Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
title_sort structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/51b05c6e4427465ea9174681f26b1d76
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AT arakoh structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT olofstenstrom structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT muhammadtanweerkhan structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT annikalundqvist structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT mikaelakke structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT fredrikbackhed structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
AT karinlindkvistpetersson structuralcharacterizationofthemicrobialenzymeurocanatereductasemediatingimidazolepropionateproduction
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