HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
Many patients fail to respond to T cell based immunotherapies. Here, the authors, through a high-throughput screening, identify HSP90 inhibitors as a class of preferred drugs for treatment combination with immunotherapy.
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/51b2a4e16a0b435cabee2477f3975980 |
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oai:doaj.org-article:51b2a4e16a0b435cabee2477f39759802021-12-02T14:41:20ZHSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes10.1038/s41467-017-00449-z2041-1723https://doaj.org/article/51b2a4e16a0b435cabee2477f39759802017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00449-zhttps://doaj.org/toc/2041-1723Many patients fail to respond to T cell based immunotherapies. Here, the authors, through a high-throughput screening, identify HSP90 inhibitors as a class of preferred drugs for treatment combination with immunotherapy.Rina M. MbofungJodi A. McKenzieShruti MaluMin ZhangWeiyi PengChengwen LiuIsere KuiatseTrang TieuLeila WilliamsSeram DeviEmily AshkinChunyu XuLu HuangMinying ZhangAmjad H. TalukderSatyendra C. TripathiHiep KhongNikunj SataniFlorian L. MullerJason RoszikTimothy HeffernanJames P. AllisonGregory LizeeSam M. HanashDavid ProiaRodabe AmariaR. Eric DavisPatrick HwuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Rina M. Mbofung Jodi A. McKenzie Shruti Malu Min Zhang Weiyi Peng Chengwen Liu Isere Kuiatse Trang Tieu Leila Williams Seram Devi Emily Ashkin Chunyu Xu Lu Huang Minying Zhang Amjad H. Talukder Satyendra C. Tripathi Hiep Khong Nikunj Satani Florian L. Muller Jason Roszik Timothy Heffernan James P. Allison Gregory Lizee Sam M. Hanash David Proia Rodabe Amaria R. Eric Davis Patrick Hwu HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes |
| description |
Many patients fail to respond to T cell based immunotherapies. Here, the authors, through a high-throughput screening, identify HSP90 inhibitors as a class of preferred drugs for treatment combination with immunotherapy. |
| format |
article |
| author |
Rina M. Mbofung Jodi A. McKenzie Shruti Malu Min Zhang Weiyi Peng Chengwen Liu Isere Kuiatse Trang Tieu Leila Williams Seram Devi Emily Ashkin Chunyu Xu Lu Huang Minying Zhang Amjad H. Talukder Satyendra C. Tripathi Hiep Khong Nikunj Satani Florian L. Muller Jason Roszik Timothy Heffernan James P. Allison Gregory Lizee Sam M. Hanash David Proia Rodabe Amaria R. Eric Davis Patrick Hwu |
| author_facet |
Rina M. Mbofung Jodi A. McKenzie Shruti Malu Min Zhang Weiyi Peng Chengwen Liu Isere Kuiatse Trang Tieu Leila Williams Seram Devi Emily Ashkin Chunyu Xu Lu Huang Minying Zhang Amjad H. Talukder Satyendra C. Tripathi Hiep Khong Nikunj Satani Florian L. Muller Jason Roszik Timothy Heffernan James P. Allison Gregory Lizee Sam M. Hanash David Proia Rodabe Amaria R. Eric Davis Patrick Hwu |
| author_sort |
Rina M. Mbofung |
| title |
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes |
| title_short |
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes |
| title_full |
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes |
| title_fullStr |
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes |
| title_full_unstemmed |
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes |
| title_sort |
hsp90 inhibition enhances cancer immunotherapy by upregulating interferon response genes |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/51b2a4e16a0b435cabee2477f3975980 |
| work_keys_str_mv |
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1718389930387832832 |