Human brain functional areas of unitary pooled activity discovered with fMRI

Abstract We report the discovery of human brain functional areas of unitary pooled activity (FAUPAs) using fMRI. A FAUPA is defined as an area in which the temporal variation of the activity is the same across the entire area. This dynamically unitary activity implies a perfect temporal correlation...

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Autor principal:	Jie Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51b812d8d5a84449a3d1abeb48796b06
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spelling	oai:doaj.org-article:51b812d8d5a84449a3d1abeb48796b062021-12-02T15:09:08ZHuman brain functional areas of unitary pooled activity discovered with fMRI10.1038/s41598-018-20778-32045-2322https://doaj.org/article/51b812d8d5a84449a3d1abeb48796b062018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20778-3https://doaj.org/toc/2045-2322Abstract We report the discovery of human brain functional areas of unitary pooled activity (FAUPAs) using fMRI. A FAUPA is defined as an area in which the temporal variation of the activity is the same across the entire area. This dynamically unitary activity implies a perfect temporal correlation everywhere within the FAUPA for the activity-induced BOLD response, i.e., the corresponding Pearson correlation coefficient (R) is 1 for the BOLD responses of any two locations within the FAUPA. A novel method was developed to identify the FAUPA. In this study, nine subjects had a resting-state (rs) fMRI and a task-fMRI. FAUPAs have been identified for both rs- and task-fMRI, and their determination was objective and automatic, with no a-priori knowledge. The group mean of R was 0.952 ± 0.004 for the rs-fMRI and 0.950 ± 0.002 for the task-fMRI, showing the dynamically unitary activity within each FAUPA. For the finger-tapping (FT) task, the group-mean BOLD signal time course of the FT-associated FAUPAs in the primary motor cortex was almost perfectly correlated with the FT-induced ideal response (R = 0.9330, P = 1.8 × 10−56), confirming the association of the FAUPA with the task. A task-associated FAUPA may play the role of a functional unit for a particular neural computation.Jie HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie Huang Human brain functional areas of unitary pooled activity discovered with fMRI
description	Abstract We report the discovery of human brain functional areas of unitary pooled activity (FAUPAs) using fMRI. A FAUPA is defined as an area in which the temporal variation of the activity is the same across the entire area. This dynamically unitary activity implies a perfect temporal correlation everywhere within the FAUPA for the activity-induced BOLD response, i.e., the corresponding Pearson correlation coefficient (R) is 1 for the BOLD responses of any two locations within the FAUPA. A novel method was developed to identify the FAUPA. In this study, nine subjects had a resting-state (rs) fMRI and a task-fMRI. FAUPAs have been identified for both rs- and task-fMRI, and their determination was objective and automatic, with no a-priori knowledge. The group mean of R was 0.952 ± 0.004 for the rs-fMRI and 0.950 ± 0.002 for the task-fMRI, showing the dynamically unitary activity within each FAUPA. For the finger-tapping (FT) task, the group-mean BOLD signal time course of the FT-associated FAUPAs in the primary motor cortex was almost perfectly correlated with the FT-induced ideal response (R = 0.9330, P = 1.8 × 10−56), confirming the association of the FAUPA with the task. A task-associated FAUPA may play the role of a functional unit for a particular neural computation.
format	article
author	Jie Huang
author_facet	Jie Huang
author_sort	Jie Huang
title	Human brain functional areas of unitary pooled activity discovered with fMRI
title_short	Human brain functional areas of unitary pooled activity discovered with fMRI
title_full	Human brain functional areas of unitary pooled activity discovered with fMRI
title_fullStr	Human brain functional areas of unitary pooled activity discovered with fMRI
title_full_unstemmed	Human brain functional areas of unitary pooled activity discovered with fMRI
title_sort	human brain functional areas of unitary pooled activity discovered with fmri
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/51b812d8d5a84449a3d1abeb48796b06
work_keys_str_mv	AT jiehuang humanbrainfunctionalareasofunitarypooledactivitydiscoveredwithfmri
_version_	1718387873263124480

Human brain functional areas of unitary pooled activity discovered with fMRI

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