Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.

Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.

G protein-coupled receptors (GPCRs) are a superfamily of seven transmembrane-spanning proteins involved in a wide array of physiological functions and are the most common targets of pharmaceuticals. This study aims to identify a cohort or clique of positions that share high mutual information. Using...

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Autores principales: Sarosh N Fatakia, Stefano Costanzi, Carson C Chow
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/51bd1cfad5ce416488bd94b296ed560a
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