Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells

Carbon nanodots (CNDs) have widely received great attention as a result of favorable optical, electrical, optoelectrical, biocompatible, and non-toxic properties these nanoparticles possess. However, the exploration of nanoparticle from natural raw material was limited. In present work, the carbon d...

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Autores principales:	Yaung Kwee, Alfinda Novi Kristanti, Nanik Siti Aminah, Mochamad Zakki Fahmi
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2020
Materias:	uncaria gambir catechin carbon nanodots staining tumor cells Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/51beea0cca6949ebb25c511bbcd6922d
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spelling	oai:doaj.org-article:51beea0cca6949ebb25c511bbcd6922d2021-12-02T16:11:23ZDesign of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells1411-94202460-157810.22146/ijc.50327https://doaj.org/article/51beea0cca6949ebb25c511bbcd6922d2020-07-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/50327https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578Carbon nanodots (CNDs) have widely received great attention as a result of favorable optical, electrical, optoelectrical, biocompatible, and non-toxic properties these nanoparticles possess. However, the exploration of nanoparticle from natural raw material was limited. In present work, the carbon dots were produced from catechin isolated from Uncaria gambir through a simple and facile process. Carbon nanodots were further produced by the pyrolysis process of catechin, which allowed it for carbonization. Owing to its unique properties such as photoluminescence with an emission peak at 500 nm (lex = 380 nm), average size diameter about 5 nm and non-toxic; Cat-CNDs were incredibly potential for staining targeted tumor cells. The staining ability by confocal microscopy observations showed their green fluorescence images which meant that the CNDs easily penetrated HeLa cells via endocytosis. The resulting CNDs which were analyzed using some significant techniques approved that the prepared Cat-CNDs were tremendously dispersible and water-soluble, good colloidal stability, excellent biocompatibility, favorable hydrophilicity, high photostability, and non-toxicity.Yaung KweeAlfinda Novi KristantiNanik Siti AminahMochamad Zakki FahmiDepartment of Chemistry, Universitas Gadjah Madaarticleuncaria gambircatechincarbon nanodotsstaining tumor cellsChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 20, Iss 6, Pp 1332-1346 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	uncaria gambir catechin carbon nanodots staining tumor cells Chemistry QD1-999
spellingShingle	uncaria gambir catechin carbon nanodots staining tumor cells Chemistry QD1-999 Yaung Kwee Alfinda Novi Kristanti Nanik Siti Aminah Mochamad Zakki Fahmi Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells
description	Carbon nanodots (CNDs) have widely received great attention as a result of favorable optical, electrical, optoelectrical, biocompatible, and non-toxic properties these nanoparticles possess. However, the exploration of nanoparticle from natural raw material was limited. In present work, the carbon dots were produced from catechin isolated from Uncaria gambir through a simple and facile process. Carbon nanodots were further produced by the pyrolysis process of catechin, which allowed it for carbonization. Owing to its unique properties such as photoluminescence with an emission peak at 500 nm (lex = 380 nm), average size diameter about 5 nm and non-toxic; Cat-CNDs were incredibly potential for staining targeted tumor cells. The staining ability by confocal microscopy observations showed their green fluorescence images which meant that the CNDs easily penetrated HeLa cells via endocytosis. The resulting CNDs which were analyzed using some significant techniques approved that the prepared Cat-CNDs were tremendously dispersible and water-soluble, good colloidal stability, excellent biocompatibility, favorable hydrophilicity, high photostability, and non-toxicity.
format	article
author	Yaung Kwee Alfinda Novi Kristanti Nanik Siti Aminah Mochamad Zakki Fahmi
author_facet	Yaung Kwee Alfinda Novi Kristanti Nanik Siti Aminah Mochamad Zakki Fahmi
author_sort	Yaung Kwee
title	Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells
title_short	Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells
title_full	Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells
title_fullStr	Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells
title_full_unstemmed	Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells
title_sort	design of catechin-based carbon nanodots as facile staining agents of tumor cells
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/51beea0cca6949ebb25c511bbcd6922d
work_keys_str_mv	AT yaungkwee designofcatechinbasedcarbonnanodotsasfacilestainingagentsoftumorcells AT alfindanovikristanti designofcatechinbasedcarbonnanodotsasfacilestainingagentsoftumorcells AT naniksitiaminah designofcatechinbasedcarbonnanodotsasfacilestainingagentsoftumorcells AT mochamadzakkifahmi designofcatechinbasedcarbonnanodotsasfacilestainingagentsoftumorcells
_version_	1718384409088884736

Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells

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