Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.

<h4>Background</h4>Carcinoembryonic antigen (CEA) is a tumor marker overexpressed in adenocarcinoma that has proinflammatory properties. Recent studies have reported that CEA is positively associated with carotid atherosclerosis and metabolic syndrome. Because visceral obesity is a known...

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Autores principales:	Jee-Yon Lee, Hyang-Kyu Lee, Duk-Chul Lee, Ji-Won Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51bf0fba7a544016b4368de7d9901791
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spelling	oai:doaj.org-article:51bf0fba7a544016b4368de7d99017912021-11-18T07:07:34ZSerum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.1932-620310.1371/journal.pone.0043518https://doaj.org/article/51bf0fba7a544016b4368de7d99017912012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952699/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Carcinoembryonic antigen (CEA) is a tumor marker overexpressed in adenocarcinoma that has proinflammatory properties. Recent studies have reported that CEA is positively associated with carotid atherosclerosis and metabolic syndrome. Because visceral obesity is a known risk factor for cardiometabolic diseases, CEA may also be associated with visceral adiposity. Therefore, we investigated the relationship between serum CEA concentration and visceral obesity in female Korean nonsmokers.<h4>Methods</h4>A total of 270 Korean female nonsmokers were enrolled during their routine health check-ups. Biomarkers of metabolic risk factors were assessed along with body composition by computed tomography. Serum CEA levels were measured by using a chemiluminescence immunoassay analyzer.<h4>Results</h4>Serum CEA levels correlated with visceral fat area, fasting glucose, and triglyceride levels after adjusting for age and BMI. The mean visceral fat area increased significantly with the increasing CEA tirtiles. In a step-wise multiple regression analysis, age (β = 0.26, p<0.01) and visceral fat area (β = 0.19, p = 0.03) were identified as explanatory variables for serum CEA level.<h4>Conclusions</h4>This study suggested that CEA may be a mediator that links metabolic disturbance and tumorigenesis in visceral obesity. Further studies are required to better understand the clinical and pathophysiological significance of our findings.Jee-Yon LeeHyang-Kyu LeeDuk-Chul LeeJi-Won LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43518 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jee-Yon Lee Hyang-Kyu Lee Duk-Chul Lee Ji-Won Lee Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.
description	<h4>Background</h4>Carcinoembryonic antigen (CEA) is a tumor marker overexpressed in adenocarcinoma that has proinflammatory properties. Recent studies have reported that CEA is positively associated with carotid atherosclerosis and metabolic syndrome. Because visceral obesity is a known risk factor for cardiometabolic diseases, CEA may also be associated with visceral adiposity. Therefore, we investigated the relationship between serum CEA concentration and visceral obesity in female Korean nonsmokers.<h4>Methods</h4>A total of 270 Korean female nonsmokers were enrolled during their routine health check-ups. Biomarkers of metabolic risk factors were assessed along with body composition by computed tomography. Serum CEA levels were measured by using a chemiluminescence immunoassay analyzer.<h4>Results</h4>Serum CEA levels correlated with visceral fat area, fasting glucose, and triglyceride levels after adjusting for age and BMI. The mean visceral fat area increased significantly with the increasing CEA tirtiles. In a step-wise multiple regression analysis, age (β = 0.26, p<0.01) and visceral fat area (β = 0.19, p = 0.03) were identified as explanatory variables for serum CEA level.<h4>Conclusions</h4>This study suggested that CEA may be a mediator that links metabolic disturbance and tumorigenesis in visceral obesity. Further studies are required to better understand the clinical and pathophysiological significance of our findings.
format	article
author	Jee-Yon Lee Hyang-Kyu Lee Duk-Chul Lee Ji-Won Lee
author_facet	Jee-Yon Lee Hyang-Kyu Lee Duk-Chul Lee Ji-Won Lee
author_sort	Jee-Yon Lee
title	Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.
title_short	Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.
title_full	Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.
title_fullStr	Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.
title_full_unstemmed	Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.
title_sort	serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female korean nonsmokers.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/51bf0fba7a544016b4368de7d9901791
work_keys_str_mv	AT jeeyonlee serumcarcinoembryonicantigenisassociatedwithabdominalvisceralfataccumulationinfemalekoreannonsmokers AT hyangkyulee serumcarcinoembryonicantigenisassociatedwithabdominalvisceralfataccumulationinfemalekoreannonsmokers AT dukchullee serumcarcinoembryonicantigenisassociatedwithabdominalvisceralfataccumulationinfemalekoreannonsmokers AT jiwonlee serumcarcinoembryonicantigenisassociatedwithabdominalvisceralfataccumulationinfemalekoreannonsmokers
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Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers.

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