Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

Identification of response biomarkers is a key step towards the development of personalised care. Here, Jayson et al. identify plasma Tie2 as a biomarker for the response of the tumor vasculature to anti-angiogenics in patients with metastatic colorectal cancer, suggesting that monitoring Tie2 level...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gordon C. Jayson, Cong Zhou, Alison Backen, Laura Horsley, Kalena Marti-Marti, Danielle Shaw, Nerissa Mescallado, Andrew Clamp, Mark P. Saunders, Juan W. Valle, Saifee Mullamitha, Mike Braun, Jurjees Hasan, Delyth McEntee, Kathryn Simpson, Ross A. Little, Yvonne Watson, Susan Cheung, Caleb Roberts, Linda Ashcroft, Prakash Manoharan, Stefan J. Scherer, Olivia del Puerto, Alan Jackson, James P. B. O’Connor, Geoff J. M. Parker, Caroline Dive
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51bffec067d642f8a6e2d9a8af7b2752
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:51bffec067d642f8a6e2d9a8af7b2752
record_format	dspace
spelling	oai:doaj.org-article:51bffec067d642f8a6e2d9a8af7b27522021-12-02T16:50:10ZPlasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer10.1038/s41467-018-07174-12041-1723https://doaj.org/article/51bffec067d642f8a6e2d9a8af7b27522018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07174-1https://doaj.org/toc/2041-1723Identification of response biomarkers is a key step towards the development of personalised care. Here, Jayson et al. identify plasma Tie2 as a biomarker for the response of the tumor vasculature to anti-angiogenics in patients with metastatic colorectal cancer, suggesting that monitoring Tie2 levels may help guide therapy in the clinics.Gordon C. JaysonCong ZhouAlison BackenLaura HorsleyKalena Marti-MartiDanielle ShawNerissa MescalladoAndrew ClampMark P. SaundersJuan W. ValleSaifee MullamithaMike BraunJurjees HasanDelyth McEnteeKathryn SimpsonRoss A. LittleYvonne WatsonSusan CheungCaleb RobertsLinda AshcroftPrakash ManoharanStefan J. SchererOlivia del PuertoAlan JacksonJames P. B. O’ConnorGeoff J. M. ParkerCaroline DiveNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gordon C. Jayson Cong Zhou Alison Backen Laura Horsley Kalena Marti-Marti Danielle Shaw Nerissa Mescallado Andrew Clamp Mark P. Saunders Juan W. Valle Saifee Mullamitha Mike Braun Jurjees Hasan Delyth McEntee Kathryn Simpson Ross A. Little Yvonne Watson Susan Cheung Caleb Roberts Linda Ashcroft Prakash Manoharan Stefan J. Scherer Olivia del Puerto Alan Jackson James P. B. O’Connor Geoff J. M. Parker Caroline Dive Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer
description	Identification of response biomarkers is a key step towards the development of personalised care. Here, Jayson et al. identify plasma Tie2 as a biomarker for the response of the tumor vasculature to anti-angiogenics in patients with metastatic colorectal cancer, suggesting that monitoring Tie2 levels may help guide therapy in the clinics.
format	article
author	Gordon C. Jayson Cong Zhou Alison Backen Laura Horsley Kalena Marti-Marti Danielle Shaw Nerissa Mescallado Andrew Clamp Mark P. Saunders Juan W. Valle Saifee Mullamitha Mike Braun Jurjees Hasan Delyth McEntee Kathryn Simpson Ross A. Little Yvonne Watson Susan Cheung Caleb Roberts Linda Ashcroft Prakash Manoharan Stefan J. Scherer Olivia del Puerto Alan Jackson James P. B. O’Connor Geoff J. M. Parker Caroline Dive
author_facet	Gordon C. Jayson Cong Zhou Alison Backen Laura Horsley Kalena Marti-Marti Danielle Shaw Nerissa Mescallado Andrew Clamp Mark P. Saunders Juan W. Valle Saifee Mullamitha Mike Braun Jurjees Hasan Delyth McEntee Kathryn Simpson Ross A. Little Yvonne Watson Susan Cheung Caleb Roberts Linda Ashcroft Prakash Manoharan Stefan J. Scherer Olivia del Puerto Alan Jackson James P. B. O’Connor Geoff J. M. Parker Caroline Dive
author_sort	Gordon C. Jayson
title	Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer
title_short	Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer
title_full	Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer
title_fullStr	Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer
title_full_unstemmed	Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer
title_sort	plasma tie2 is a tumor vascular response biomarker for vegf inhibitors in metastatic colorectal cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/51bffec067d642f8a6e2d9a8af7b2752
work_keys_str_mv	AT gordoncjayson plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT congzhou plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT alisonbacken plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT laurahorsley plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT kalenamartimarti plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT danielleshaw plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT nerissamescallado plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT andrewclamp plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT markpsaunders plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT juanwvalle plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT saifeemullamitha plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT mikebraun plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT jurjeeshasan plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT delythmcentee plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT kathrynsimpson plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT rossalittle plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT yvonnewatson plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT susancheung plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT calebroberts plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT lindaashcroft plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT prakashmanoharan plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT stefanjscherer plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT oliviadelpuerto plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT alanjackson plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT jamespboconnor plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT geoffjmparker plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer AT carolinedive plasmatie2isatumorvascularresponsebiomarkerforvegfinhibitorsinmetastaticcolorectalcancer
_version_	1718383097973571584

Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

Ejemplares similares