MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES

Abstract. Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human...

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Autores principales:	A. Il’inskaya, L. Pichugina, N. Oliferuk, V. L’vov, B. Pinegin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	macrophages muramyl peptides maturation il_12, tnfα il_6 phagocytosis bactericidal activity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/51c0f8b8d81b4c429ab9c7acdfb8bac4
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spelling	oai:doaj.org-article:51c0f8b8d81b4c429ab9c7acdfb8bac42021-11-18T08:03:41ZMATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES1563-06252313-741X10.15789/1563-0625-2005-1-21-26https://doaj.org/article/51c0f8b8d81b4c429ab9c7acdfb8bac42014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/399https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human macrophages exposed to muramyl peptides showed the increasing expression of costimulatory receptors and antigen presenting molecules. On the other hand, there was downregulation of receptors involved in recognition and engulfing of microorganism. In response to bacterial component macrophages secreted several cytokines: IL–12, TNFα, IL–6. (Med. Immunol., 2005, vol.7, № 1, pp. 21526)A. Il’inskayaL. PichuginaN. OliferukV. L’vovB. PineginSPb RAACIarticlemacrophagesmuramyl peptidesmaturationil_12, tnfαil_6phagocytosisbactericidal activityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 1, Pp 21-26 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	macrophages muramyl peptides maturation il_12, tnfα il_6 phagocytosis bactericidal activity Immunologic diseases. Allergy RC581-607
spellingShingle	macrophages muramyl peptides maturation il_12, tnfα il_6 phagocytosis bactericidal activity Immunologic diseases. Allergy RC581-607 A. Il’inskaya L. Pichugina N. Oliferuk V. L’vov B. Pinegin MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES
description	Abstract. Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human macrophages exposed to muramyl peptides showed the increasing expression of costimulatory receptors and antigen presenting molecules. On the other hand, there was downregulation of receptors involved in recognition and engulfing of microorganism. In response to bacterial component macrophages secreted several cytokines: IL–12, TNFα, IL–6. (Med. Immunol., 2005, vol.7, № 1, pp. 21526)
format	article
author	A. Il’inskaya L. Pichugina N. Oliferuk V. L’vov B. Pinegin
author_facet	A. Il’inskaya L. Pichugina N. Oliferuk V. L’vov B. Pinegin
author_sort	A. Il’inskaya
title	MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES
title_short	MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES
title_full	MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES
title_fullStr	MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES
title_full_unstemmed	MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES
title_sort	maturation of macrophages under the influence of muramyl peptides
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/51c0f8b8d81b4c429ab9c7acdfb8bac4
work_keys_str_mv	AT ailinskaya maturationofmacrophagesundertheinfluenceofmuramylpeptides AT lpichugina maturationofmacrophagesundertheinfluenceofmuramylpeptides AT noliferuk maturationofmacrophagesundertheinfluenceofmuramylpeptides AT vlvov maturationofmacrophagesundertheinfluenceofmuramylpeptides AT bpinegin maturationofmacrophagesundertheinfluenceofmuramylpeptides
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MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES

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