Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.

<h4>Background</h4>Administration of psychomotor stimulants like amphetamine facilitates behavior in the presence of incentive distal stimuli, which have acquired the motivational properties of primary rewards through associative learning. This facilitation appears to be mediated by the...

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Autores principales:	Rick Shin, Junran Cao, Sierra M Webb, Satoshi Ikemoto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51c3d6ad428f423ea50ddf0163d826c3
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spelling	oai:doaj.org-article:51c3d6ad428f423ea50ddf0163d826c32021-12-02T20:11:58ZAmphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.1932-620310.1371/journal.pone.0008741https://doaj.org/article/51c3d6ad428f423ea50ddf0163d826c32010-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20090902/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Administration of psychomotor stimulants like amphetamine facilitates behavior in the presence of incentive distal stimuli, which have acquired the motivational properties of primary rewards through associative learning. This facilitation appears to be mediated by the mesolimbic dopamine system, which may also be involved in facilitating behavior in the presence of distal stimuli that have not been previously paired with primary rewards. However, it is unclear whether psychomotor stimulants facilitate behavioral interaction with unconditioned distal stimuli.<h4>Principal findings</h4>We found that noncontingent administration of amphetamine into subregions of the rat ventral striatum, particularly in the vicinity of the medial olfactory tubercle, facilitates lever pressing followed by visual signals that had not been paired with primary rewards. Noncontingent administration of amphetamine failed to facilitate lever pressing when it was followed by either tones or delayed presentation or absence of visual signals, suggesting that visual signals are key for enhanced behavioral interaction. Systemic administration of amphetamine markedly increased locomotor activity, but did not necessarily increase lever pressing rewarded by visual signals, suggesting that lever pressing is not a byproduct of heightened locomotor activity. Lever pressing facilitated by amphetamine was reduced by co-administration of the dopamine receptor antagonists SCH 23390 (D1 selective) or sulpiride (D2 selective).<h4>Conclusions</h4>Our results suggest that amphetamine administration into the ventral striatum, particularly in the vicinity of the medial olfactory tubercle, activates dopaminergic mechanisms that strongly enhance behavioral interaction with unconditioned visual stimuli.Rick ShinJunran CaoSierra M WebbSatoshi IkemotoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 1, p e8741 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rick Shin Junran Cao Sierra M Webb Satoshi Ikemoto Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.
description	<h4>Background</h4>Administration of psychomotor stimulants like amphetamine facilitates behavior in the presence of incentive distal stimuli, which have acquired the motivational properties of primary rewards through associative learning. This facilitation appears to be mediated by the mesolimbic dopamine system, which may also be involved in facilitating behavior in the presence of distal stimuli that have not been previously paired with primary rewards. However, it is unclear whether psychomotor stimulants facilitate behavioral interaction with unconditioned distal stimuli.<h4>Principal findings</h4>We found that noncontingent administration of amphetamine into subregions of the rat ventral striatum, particularly in the vicinity of the medial olfactory tubercle, facilitates lever pressing followed by visual signals that had not been paired with primary rewards. Noncontingent administration of amphetamine failed to facilitate lever pressing when it was followed by either tones or delayed presentation or absence of visual signals, suggesting that visual signals are key for enhanced behavioral interaction. Systemic administration of amphetamine markedly increased locomotor activity, but did not necessarily increase lever pressing rewarded by visual signals, suggesting that lever pressing is not a byproduct of heightened locomotor activity. Lever pressing facilitated by amphetamine was reduced by co-administration of the dopamine receptor antagonists SCH 23390 (D1 selective) or sulpiride (D2 selective).<h4>Conclusions</h4>Our results suggest that amphetamine administration into the ventral striatum, particularly in the vicinity of the medial olfactory tubercle, activates dopaminergic mechanisms that strongly enhance behavioral interaction with unconditioned visual stimuli.
format	article
author	Rick Shin Junran Cao Sierra M Webb Satoshi Ikemoto
author_facet	Rick Shin Junran Cao Sierra M Webb Satoshi Ikemoto
author_sort	Rick Shin
title	Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.
title_short	Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.
title_full	Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.
title_fullStr	Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.
title_full_unstemmed	Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.
title_sort	amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/51c3d6ad428f423ea50ddf0163d826c3
work_keys_str_mv	AT rickshin amphetamineadministrationintotheventralstriatumfacilitatesbehavioralinteractionwithunconditionedvisualsignalsinrats AT junrancao amphetamineadministrationintotheventralstriatumfacilitatesbehavioralinteractionwithunconditionedvisualsignalsinrats AT sierramwebb amphetamineadministrationintotheventralstriatumfacilitatesbehavioralinteractionwithunconditionedvisualsignalsinrats AT satoshiikemoto amphetamineadministrationintotheventralstriatumfacilitatesbehavioralinteractionwithunconditionedvisualsignalsinrats
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Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.

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