Elastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation

Herein, in the present work two series of thermoplastic polyurethane (TPU) nanofibers were manufactured using the electrospinning techniques with ZnO and CuO nanoparticles for a potential use as an elastic functional layer in antimicrobial applications. Percentages of 0%, 2 wt%, and 4 wt% of the nan...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Latifah Abdullah Alshabanah, Nada Omran, Bassma H. Elwakil, Moaaz T. Hamed, Salwa M. Abdallah, Laila A. Al-Mutabagani, Dong Wang, Qiongzhen Liu, Nader Shehata, Ahmed H. Hassanin, Mohamed Hagar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanofibers electrospinning anti colistin resistant bacteria antiviral personal protective equipment Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/51ca2e618ccd47ee9617ccfd15554a7e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:51ca2e618ccd47ee9617ccfd15554a7e
record_format	dspace
spelling	oai:doaj.org-article:51ca2e618ccd47ee9617ccfd15554a7e2021-11-25T18:49:09ZElastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation10.3390/polym132239872073-4360https://doaj.org/article/51ca2e618ccd47ee9617ccfd15554a7e2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3987https://doaj.org/toc/2073-4360Herein, in the present work two series of thermoplastic polyurethane (TPU) nanofibers were manufactured using the electrospinning techniques with ZnO and CuO nanoparticles for a potential use as an elastic functional layer in antimicrobial applications. Percentages of 0%, 2 wt%, and 4 wt% of the nanoparticles were used. The morphological characterization of the electrospun TPU and TPU/NPs composites nanofibers were observed by using scanning electron microscopy to show the average fiber diameter and it was in the range of 90–150 nm with a significant impact of the nanoparticle type. Mechanical characterization showed that TPU nanofiber membranes exhibit excellent mechanical properties with ultra-high elastic properties. Elongation at break reached up to 92.5%. The assessment of the developed nanofiber membranes for medical and personal protection applications was done against various colistin resistant bacterial strains and the results showed an increment activity by increasing the metal oxide concentration up to 83% reduction rate by using TPU/ZnO 4% nanofibers against <i>K. pneumoniae</i> strain 10. The bacterial growth was completely eradicated after 8 and 16 h incubation with TPU/ZnO and TPU/CuO nanofibers, respectively. The nanofibers SEM study reveals the adsorption of the bacterial cells on the metal oxides nanofibers surface which led to cell lysis and releasing of their content. Finally, in vitro study against Spike S-protein from SARS-CoV-2 was also evaluated to investigate the potent effectiveness of the proposed nanofibers in the virus deactivation. The results showed that the metal oxide concentration is an effective factor in the antiviral activity due to the observed pattern of increasing the antibacterial and antiviral activity by increasing the metal oxide concentration; however, TPU/ZnO nanofibers showed a potent antiviral activity in relation to TPU/CuO.Latifah Abdullah AlshabanahNada OmranBassma H. ElwakilMoaaz T. HamedSalwa M. AbdallahLaila A. Al-MutabaganiDong WangQiongzhen LiuNader ShehataAhmed H. HassaninMohamed HagarMDPI AGarticlenanofiberselectrospinninganti colistin resistant bacteriaantiviralpersonal protective equipmentOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3987, p 3987 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanofibers electrospinning anti colistin resistant bacteria antiviral personal protective equipment Organic chemistry QD241-441
spellingShingle	nanofibers electrospinning anti colistin resistant bacteria antiviral personal protective equipment Organic chemistry QD241-441 Latifah Abdullah Alshabanah Nada Omran Bassma H. Elwakil Moaaz T. Hamed Salwa M. Abdallah Laila A. Al-Mutabagani Dong Wang Qiongzhen Liu Nader Shehata Ahmed H. Hassanin Mohamed Hagar Elastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation
description	Herein, in the present work two series of thermoplastic polyurethane (TPU) nanofibers were manufactured using the electrospinning techniques with ZnO and CuO nanoparticles for a potential use as an elastic functional layer in antimicrobial applications. Percentages of 0%, 2 wt%, and 4 wt% of the nanoparticles were used. The morphological characterization of the electrospun TPU and TPU/NPs composites nanofibers were observed by using scanning electron microscopy to show the average fiber diameter and it was in the range of 90–150 nm with a significant impact of the nanoparticle type. Mechanical characterization showed that TPU nanofiber membranes exhibit excellent mechanical properties with ultra-high elastic properties. Elongation at break reached up to 92.5%. The assessment of the developed nanofiber membranes for medical and personal protection applications was done against various colistin resistant bacterial strains and the results showed an increment activity by increasing the metal oxide concentration up to 83% reduction rate by using TPU/ZnO 4% nanofibers against <i>K. pneumoniae</i> strain 10. The bacterial growth was completely eradicated after 8 and 16 h incubation with TPU/ZnO and TPU/CuO nanofibers, respectively. The nanofibers SEM study reveals the adsorption of the bacterial cells on the metal oxides nanofibers surface which led to cell lysis and releasing of their content. Finally, in vitro study against Spike S-protein from SARS-CoV-2 was also evaluated to investigate the potent effectiveness of the proposed nanofibers in the virus deactivation. The results showed that the metal oxide concentration is an effective factor in the antiviral activity due to the observed pattern of increasing the antibacterial and antiviral activity by increasing the metal oxide concentration; however, TPU/ZnO nanofibers showed a potent antiviral activity in relation to TPU/CuO.
format	article
author	Latifah Abdullah Alshabanah Nada Omran Bassma H. Elwakil Moaaz T. Hamed Salwa M. Abdallah Laila A. Al-Mutabagani Dong Wang Qiongzhen Liu Nader Shehata Ahmed H. Hassanin Mohamed Hagar
author_facet	Latifah Abdullah Alshabanah Nada Omran Bassma H. Elwakil Moaaz T. Hamed Salwa M. Abdallah Laila A. Al-Mutabagani Dong Wang Qiongzhen Liu Nader Shehata Ahmed H. Hassanin Mohamed Hagar
author_sort	Latifah Abdullah Alshabanah
title	Elastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation
title_short	Elastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation
title_full	Elastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation
title_fullStr	Elastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation
title_full_unstemmed	Elastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation
title_sort	elastic nanofibrous membranes for medical and personal protection applications: manufacturing, anti-covid-19, and anti-colistin resistant bacteria evaluation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/51ca2e618ccd47ee9617ccfd15554a7e
work_keys_str_mv	AT latifahabdullahalshabanah elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT nadaomran elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT bassmahelwakil elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT moaazthamed elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT salwamabdallah elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT lailaaalmutabagani elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT dongwang elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT qiongzhenliu elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT nadershehata elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT ahmedhhassanin elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation AT mohamedhagar elasticnanofibrousmembranesformedicalandpersonalprotectionapplicationsmanufacturinganticovid19andanticolistinresistantbacteriaevaluation
_version_	1718410646958112768

Elastic Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19, and Anti-Colistin Resistant Bacteria Evaluation

Ejemplares similares