Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis

The bacterial second messenger cyclic di-AMP (c-di-AMP) is a global regulator of potassium homeostasis and compatible solute uptake in many Gram-positive bacteria, making it essential for osmoregulation. The role that c-di-AMP plays in β-lactam resistance, however, is unclear despite being first id...

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Autores principales:	Huong Thi Pham, Wen Shi, Yuwei Xiang, Su Yi Foo, Manuel R. Plan, Pascal Courtin, Marie-Pierre Chapot-Chartier, Eddy J. Smid, Zhao-Xun Liang, Esteban Marcellin, Mark S. Turner
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/51d41b28483845b1aafb29b142c5338c
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spelling	oai:doaj.org-article:51d41b28483845b1aafb29b142c5338c2021-11-03T18:56:09ZCyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis2150-751110.1128/mBio.00324-21https://doaj.org/article/51d41b28483845b1aafb29b142c5338c2021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00324-21https://doaj.org/toc/2150-7511 The bacterial second messenger cyclic di-AMP (c-di-AMP) is a global regulator of potassium homeostasis and compatible solute uptake in many Gram-positive bacteria, making it essential for osmoregulation. The role that c-di-AMP plays in β-lactam resistance, however, is unclear despite being first identified a decade ago.Huong Thi PhamWen ShiYuwei XiangSu Yi FooManuel R. PlanPascal CourtinMarie-Pierre Chapot-ChartierEddy J. SmidZhao-Xun LiangEsteban MarcellinMark S. TurnerAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Huong Thi Pham Wen Shi Yuwei Xiang Su Yi Foo Manuel R. Plan Pascal Courtin Marie-Pierre Chapot-Chartier Eddy J. Smid Zhao-Xun Liang Esteban Marcellin Mark S. Turner Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis
description	The bacterial second messenger cyclic di-AMP (c-di-AMP) is a global regulator of potassium homeostasis and compatible solute uptake in many Gram-positive bacteria, making it essential for osmoregulation. The role that c-di-AMP plays in β-lactam resistance, however, is unclear despite being first identified a decade ago.
format	article
author	Huong Thi Pham Wen Shi Yuwei Xiang Su Yi Foo Manuel R. Plan Pascal Courtin Marie-Pierre Chapot-Chartier Eddy J. Smid Zhao-Xun Liang Esteban Marcellin Mark S. Turner
author_facet	Huong Thi Pham Wen Shi Yuwei Xiang Su Yi Foo Manuel R. Plan Pascal Courtin Marie-Pierre Chapot-Chartier Eddy J. Smid Zhao-Xun Liang Esteban Marcellin Mark S. Turner
author_sort	Huong Thi Pham
title	Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis
title_short	Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis
title_full	Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis
title_fullStr	Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis
title_full_unstemmed	Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis
title_sort	cyclic di-amp oversight of counter-ion osmolyte pools impacts intrinsic cefuroxime resistance in lactococcus lactis
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/51d41b28483845b1aafb29b142c5338c
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Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis

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