The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy

Background: To identify the role of combination biopsy, which consists of both targeted and additional systematic cores, in the diagnosis of clinically significant prostate cancer (csPCa). Methods: We retrospectively reviewed patients with PSA levels 2.5–15 ng/mL who have a suspicious prostate lesio...

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Autores principales:	Chung Un Lee, Joongwon Choi, Si Hyun Sung, Jae Hoon Chung, Wan Song, Minyong Kang, Hyun Hwan Sung, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Hwang Gyun Jeon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prostate biopsy Prostate Imaging Reporting and Data System (PI-RADS) combination targeted biopsy systematic biopsy Medicine R
Acceso en línea:	https://doaj.org/article/51d559f2a3254cb7bf2d791e4150cd9f
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spelling	oai:doaj.org-article:51d559f2a3254cb7bf2d791e4150cd9f2021-11-11T17:28:54ZThe Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy10.3390/jcm102148042077-0383https://doaj.org/article/51d559f2a3254cb7bf2d791e4150cd9f2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4804https://doaj.org/toc/2077-0383Background: To identify the role of combination biopsy, which consists of both targeted and additional systematic cores, in the diagnosis of clinically significant prostate cancer (csPCa). Methods: We retrospectively reviewed patients with PSA levels 2.5–15 ng/mL who have a suspicious prostate lesion (with the Prostate Imaging Reporting and Data System (PI-RADS) ≥ 3) on multiparametric MRI (mpMRI) between January 2016 and December 2018. We analyzed biopsy results by PI-RADS score and biopsy methods (systematic, targeted, and combination biopsy). Results: Of the 711 total patients, an average of 4.0 ± 1.8 targeted and 8.6 ± 3.1 additional systematic biopsies were performed. The additional systematic biopsies were sampled outside the targeted biopsy area. The combination biopsies detected more csPCa (201 patients, 28.3%) than did the targeted (175 patients, 24.6%) or systematic (124 patients, 17.4%) biopsies alone (<i>p</i> < 0.001). In the initial biopsy samples, there was a 7% increase in the detection of csPCa than in targeted biopsy (62% to 69%). It increased by 11% in repeat biopsy (46% to 57%). There was no statistical significance in both groups (<i>p</i> = 0.3174). Conclusions: Combination biopsy has the benefit of detecting csPCa in both initial and repeat biopsy when there is a suspicious lesion on mpMRI.Chung Un LeeJoongwon ChoiSi Hyun SungJae Hoon ChungWan SongMinyong KangHyun Hwan SungByong Chang JeongSeong Il SeoSeong Soo JeonHyun Moo LeeHwang Gyun JeonMDPI AGarticleprostate biopsyProstate Imaging Reporting and Data System (PI-RADS)combinationtargeted biopsysystematic biopsyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4804, p 4804 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate biopsy Prostate Imaging Reporting and Data System (PI-RADS) combination targeted biopsy systematic biopsy Medicine R
spellingShingle	prostate biopsy Prostate Imaging Reporting and Data System (PI-RADS) combination targeted biopsy systematic biopsy Medicine R Chung Un Lee Joongwon Choi Si Hyun Sung Jae Hoon Chung Wan Song Minyong Kang Hyun Hwan Sung Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
description	Background: To identify the role of combination biopsy, which consists of both targeted and additional systematic cores, in the diagnosis of clinically significant prostate cancer (csPCa). Methods: We retrospectively reviewed patients with PSA levels 2.5–15 ng/mL who have a suspicious prostate lesion (with the Prostate Imaging Reporting and Data System (PI-RADS) ≥ 3) on multiparametric MRI (mpMRI) between January 2016 and December 2018. We analyzed biopsy results by PI-RADS score and biopsy methods (systematic, targeted, and combination biopsy). Results: Of the 711 total patients, an average of 4.0 ± 1.8 targeted and 8.6 ± 3.1 additional systematic biopsies were performed. The additional systematic biopsies were sampled outside the targeted biopsy area. The combination biopsies detected more csPCa (201 patients, 28.3%) than did the targeted (175 patients, 24.6%) or systematic (124 patients, 17.4%) biopsies alone (<i>p</i> < 0.001). In the initial biopsy samples, there was a 7% increase in the detection of csPCa than in targeted biopsy (62% to 69%). It increased by 11% in repeat biopsy (46% to 57%). There was no statistical significance in both groups (<i>p</i> = 0.3174). Conclusions: Combination biopsy has the benefit of detecting csPCa in both initial and repeat biopsy when there is a suspicious lesion on mpMRI.
format	article
author	Chung Un Lee Joongwon Choi Si Hyun Sung Jae Hoon Chung Wan Song Minyong Kang Hyun Hwan Sung Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon
author_facet	Chung Un Lee Joongwon Choi Si Hyun Sung Jae Hoon Chung Wan Song Minyong Kang Hyun Hwan Sung Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon
author_sort	Chung Un Lee
title	The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_short	The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_full	The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_fullStr	The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_full_unstemmed	The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
title_sort	role of prostate combination biopsy consisting of targeted and additional systematic biopsy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/51d559f2a3254cb7bf2d791e4150cd9f
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The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy

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