REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

REX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 knockout phenotype in imprinted X chromosome inactiva...

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Autores principales:	Cristina Gontan, Hegias Mira-Bontenbal, Aristea Magaraki, Catherine Dupont, Tahsin Stefan Barakat, Eveline Rentmeester, Jeroen Demmers, Joost Gribnau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51d821b56da94099bdacf7d958882727
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spelling	oai:doaj.org-article:51d821b56da94099bdacf7d9588827272021-12-02T14:39:08ZREX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice10.1038/s41467-018-07060-w2041-1723https://doaj.org/article/51d821b56da94099bdacf7d9588827272018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07060-whttps://doaj.org/toc/2041-1723REX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 knockout phenotype in imprinted X chromosome inactivation in mice.Cristina GontanHegias Mira-BontenbalAristea MagarakiCatherine DupontTahsin Stefan BarakatEveline RentmeesterJeroen DemmersJoost GribnauNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristina Gontan Hegias Mira-Bontenbal Aristea Magaraki Catherine Dupont Tahsin Stefan Barakat Eveline Rentmeester Jeroen Demmers Joost Gribnau REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
description	REX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 knockout phenotype in imprinted X chromosome inactivation in mice.
format	article
author	Cristina Gontan Hegias Mira-Bontenbal Aristea Magaraki Catherine Dupont Tahsin Stefan Barakat Eveline Rentmeester Jeroen Demmers Joost Gribnau
author_facet	Cristina Gontan Hegias Mira-Bontenbal Aristea Magaraki Catherine Dupont Tahsin Stefan Barakat Eveline Rentmeester Jeroen Demmers Joost Gribnau
author_sort	Cristina Gontan
title	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_short	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_full	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_fullStr	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_full_unstemmed	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_sort	rex1 is the critical target of rnf12 in imprinted x chromosome inactivation in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/51d821b56da94099bdacf7d958882727
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REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

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