Cysteine oxidation and disulfide formation in the ribosomal exit tunnel

As protein synthesis takes place, newly synthesized polypeptide chain passes through the ribosomal exit tunnel, which can accommodate up to 70 residues in the case of a helical peptide. Here the authors show that oxidation of cysteine residues in the nascent chain can occur within the ribosome exit...

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Autores principales:	Linda Schulte, Jiafei Mao, Julian Reitz, Sridhar Sreeramulu, Denis Kudlinzki, Victor-Valentin Hodirnau, Jakob Meier-Credo, Krishna Saxena, Florian Buhr, Julian D. Langer, Martin Blackledge, Achilleas S. Frangakis, Clemens Glaubitz, Harald Schwalbe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51d8d9f03c4049bb9442760267f33527
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spelling	oai:doaj.org-article:51d8d9f03c4049bb9442760267f335272021-12-02T14:41:03ZCysteine oxidation and disulfide formation in the ribosomal exit tunnel10.1038/s41467-020-19372-x2041-1723https://doaj.org/article/51d8d9f03c4049bb9442760267f335272020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19372-xhttps://doaj.org/toc/2041-1723As protein synthesis takes place, newly synthesized polypeptide chain passes through the ribosomal exit tunnel, which can accommodate up to 70 residues in the case of a helical peptide. Here the authors show that oxidation of cysteine residues in the nascent chain can occur within the ribosome exit tunnel, where sufficient space exists for the formation of disulfide bonds.Linda SchulteJiafei MaoJulian ReitzSridhar SreeramuluDenis KudlinzkiVictor-Valentin HodirnauJakob Meier-CredoKrishna SaxenaFlorian BuhrJulian D. LangerMartin BlackledgeAchilleas S. FrangakisClemens GlaubitzHarald SchwalbeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linda Schulte Jiafei Mao Julian Reitz Sridhar Sreeramulu Denis Kudlinzki Victor-Valentin Hodirnau Jakob Meier-Credo Krishna Saxena Florian Buhr Julian D. Langer Martin Blackledge Achilleas S. Frangakis Clemens Glaubitz Harald Schwalbe Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
description	As protein synthesis takes place, newly synthesized polypeptide chain passes through the ribosomal exit tunnel, which can accommodate up to 70 residues in the case of a helical peptide. Here the authors show that oxidation of cysteine residues in the nascent chain can occur within the ribosome exit tunnel, where sufficient space exists for the formation of disulfide bonds.
format	article
author	Linda Schulte Jiafei Mao Julian Reitz Sridhar Sreeramulu Denis Kudlinzki Victor-Valentin Hodirnau Jakob Meier-Credo Krishna Saxena Florian Buhr Julian D. Langer Martin Blackledge Achilleas S. Frangakis Clemens Glaubitz Harald Schwalbe
author_facet	Linda Schulte Jiafei Mao Julian Reitz Sridhar Sreeramulu Denis Kudlinzki Victor-Valentin Hodirnau Jakob Meier-Credo Krishna Saxena Florian Buhr Julian D. Langer Martin Blackledge Achilleas S. Frangakis Clemens Glaubitz Harald Schwalbe
author_sort	Linda Schulte
title	Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
title_short	Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
title_full	Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
title_fullStr	Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
title_full_unstemmed	Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
title_sort	cysteine oxidation and disulfide formation in the ribosomal exit tunnel
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/51d8d9f03c4049bb9442760267f33527
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Cysteine oxidation and disulfide formation in the ribosomal exit tunnel

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