Development of a chemogenomics library for phenotypic screening

Abstract With the development of advanced technologies in cell-based phenotypic screening, phenotypic drug discovery (PDD) strategies have re-emerged as promising approaches in the identification and development of novel and safe drugs. However, phenotypic screening does not rely on knowledge of spe...

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Autores principales:	Bryan Dafniet, Natacha Cerisier, Batiste Boezio, Anaelle Clary, Pierre Ducrot, Thierry Dorval, Arnaud Gohier, David Brown, Karine Audouze, Olivier Taboureau
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Phenotypic screening Phenotypic drug discovery Chemical biology System pharmacology network Network pharmacology Chemogenomics Information technology T58.5-58.64 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/51da2bea68b642218bf227d50acee1a6
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spelling	oai:doaj.org-article:51da2bea68b642218bf227d50acee1a62021-11-28T12:30:25ZDevelopment of a chemogenomics library for phenotypic screening10.1186/s13321-021-00569-11758-2946https://doaj.org/article/51da2bea68b642218bf227d50acee1a62021-11-01T00:00:00Zhttps://doi.org/10.1186/s13321-021-00569-1https://doaj.org/toc/1758-2946Abstract With the development of advanced technologies in cell-based phenotypic screening, phenotypic drug discovery (PDD) strategies have re-emerged as promising approaches in the identification and development of novel and safe drugs. However, phenotypic screening does not rely on knowledge of specific drug targets and needs to be combined with chemical biology approaches to identify therapeutic targets and mechanisms of actions induced by drugs and associated with an observable phenotype. In this study, we developed a system pharmacology network integrating drug-target-pathway-disease relationships as well as morphological profile from an existing high content imaging-based high-throughput phenotypic profiling assay known as “Cell Painting”. Furthermore, from this network, a chemogenomic library of 5000 small molecules that represent a large and diverse panel of drug targets involved in diverse biological effects and diseases has been developed. Such a platform and a chemogenomic library could assist in the target identification and mechanism deconvolution of some phenotypic assays. The usefulness of the platform is illustrated through examples.Bryan DafnietNatacha CerisierBatiste BoezioAnaelle ClaryPierre DucrotThierry DorvalArnaud GohierDavid BrownKarine AudouzeOlivier TaboureauBMCarticlePhenotypic screeningPhenotypic drug discoveryChemical biologySystem pharmacology networkNetwork pharmacologyChemogenomicsInformation technologyT58.5-58.64ChemistryQD1-999ENJournal of Cheminformatics, Vol 13, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Phenotypic screening Phenotypic drug discovery Chemical biology System pharmacology network Network pharmacology Chemogenomics Information technology T58.5-58.64 Chemistry QD1-999
spellingShingle	Phenotypic screening Phenotypic drug discovery Chemical biology System pharmacology network Network pharmacology Chemogenomics Information technology T58.5-58.64 Chemistry QD1-999 Bryan Dafniet Natacha Cerisier Batiste Boezio Anaelle Clary Pierre Ducrot Thierry Dorval Arnaud Gohier David Brown Karine Audouze Olivier Taboureau Development of a chemogenomics library for phenotypic screening
description	Abstract With the development of advanced technologies in cell-based phenotypic screening, phenotypic drug discovery (PDD) strategies have re-emerged as promising approaches in the identification and development of novel and safe drugs. However, phenotypic screening does not rely on knowledge of specific drug targets and needs to be combined with chemical biology approaches to identify therapeutic targets and mechanisms of actions induced by drugs and associated with an observable phenotype. In this study, we developed a system pharmacology network integrating drug-target-pathway-disease relationships as well as morphological profile from an existing high content imaging-based high-throughput phenotypic profiling assay known as “Cell Painting”. Furthermore, from this network, a chemogenomic library of 5000 small molecules that represent a large and diverse panel of drug targets involved in diverse biological effects and diseases has been developed. Such a platform and a chemogenomic library could assist in the target identification and mechanism deconvolution of some phenotypic assays. The usefulness of the platform is illustrated through examples.
format	article
author	Bryan Dafniet Natacha Cerisier Batiste Boezio Anaelle Clary Pierre Ducrot Thierry Dorval Arnaud Gohier David Brown Karine Audouze Olivier Taboureau
author_facet	Bryan Dafniet Natacha Cerisier Batiste Boezio Anaelle Clary Pierre Ducrot Thierry Dorval Arnaud Gohier David Brown Karine Audouze Olivier Taboureau
author_sort	Bryan Dafniet
title	Development of a chemogenomics library for phenotypic screening
title_short	Development of a chemogenomics library for phenotypic screening
title_full	Development of a chemogenomics library for phenotypic screening
title_fullStr	Development of a chemogenomics library for phenotypic screening
title_full_unstemmed	Development of a chemogenomics library for phenotypic screening
title_sort	development of a chemogenomics library for phenotypic screening
publisher	BMC
publishDate	2021
url	https://doaj.org/article/51da2bea68b642218bf227d50acee1a6
work_keys_str_mv	AT bryandafniet developmentofachemogenomicslibraryforphenotypicscreening AT natachacerisier developmentofachemogenomicslibraryforphenotypicscreening AT batisteboezio developmentofachemogenomicslibraryforphenotypicscreening AT anaelleclary developmentofachemogenomicslibraryforphenotypicscreening AT pierreducrot developmentofachemogenomicslibraryforphenotypicscreening AT thierrydorval developmentofachemogenomicslibraryforphenotypicscreening AT arnaudgohier developmentofachemogenomicslibraryforphenotypicscreening AT davidbrown developmentofachemogenomicslibraryforphenotypicscreening AT karineaudouze developmentofachemogenomicslibraryforphenotypicscreening AT oliviertaboureau developmentofachemogenomicslibraryforphenotypicscreening
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Development of a chemogenomics library for phenotypic screening

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