RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma

Metastasis is a complex process by which cancer cells escape from the primary tumor to colonize distant organs. RAC1 is a member of the RHO family of small guanosine triphosphatases that plays an important role in cancer migration, invasion, angiogenesis and metastasis. RAC1 activation has been rela...

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Autores principales:	Paula Colón-Bolea, Rocío García-Gómez, Berta Casar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	RAC1 cutaneous melanoma invasion metastasis therapy resistance Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/51e13b68bf2940e4a3bc15a599bab654
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id	oai:doaj.org-article:51e13b68bf2940e4a3bc15a599bab654
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spelling	oai:doaj.org-article:51e13b68bf2940e4a3bc15a599bab6542021-11-25T16:51:44ZRAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma10.3390/biom111115542218-273Xhttps://doaj.org/article/51e13b68bf2940e4a3bc15a599bab6542021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1554https://doaj.org/toc/2218-273XMetastasis is a complex process by which cancer cells escape from the primary tumor to colonize distant organs. RAC1 is a member of the RHO family of small guanosine triphosphatases that plays an important role in cancer migration, invasion, angiogenesis and metastasis. RAC1 activation has been related to most cancers, such as cutaneous melanoma, breast, lung, and pancreatic cancer. RAC1P29S driver mutation appears in a significant number of cutaneous melanoma cases. Likewise, RAC1 is overexpressed or hyperactivated via signaling through oncogenic cell surface receptors. Thus, targeting RAC1 represents a promising strategy for cutaneous melanoma therapy, as well as for inhibition of other signaling activation that promotes resistance to targeted therapies. In this review, we focus on the role of RAC1 in metastatic cutaneous melanoma emphasizing the anti-metastatic potential of RAC1- targeting drugs.Paula Colón-BoleaRocío García-GómezBerta CasarMDPI AGarticleRAC1cutaneous melanomainvasionmetastasistherapy resistanceMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1554, p 1554 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RAC1 cutaneous melanoma invasion metastasis therapy resistance Microbiology QR1-502
spellingShingle	RAC1 cutaneous melanoma invasion metastasis therapy resistance Microbiology QR1-502 Paula Colón-Bolea Rocío García-Gómez Berta Casar RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma
description	Metastasis is a complex process by which cancer cells escape from the primary tumor to colonize distant organs. RAC1 is a member of the RHO family of small guanosine triphosphatases that plays an important role in cancer migration, invasion, angiogenesis and metastasis. RAC1 activation has been related to most cancers, such as cutaneous melanoma, breast, lung, and pancreatic cancer. RAC1P29S driver mutation appears in a significant number of cutaneous melanoma cases. Likewise, RAC1 is overexpressed or hyperactivated via signaling through oncogenic cell surface receptors. Thus, targeting RAC1 represents a promising strategy for cutaneous melanoma therapy, as well as for inhibition of other signaling activation that promotes resistance to targeted therapies. In this review, we focus on the role of RAC1 in metastatic cutaneous melanoma emphasizing the anti-metastatic potential of RAC1- targeting drugs.
format	article
author	Paula Colón-Bolea Rocío García-Gómez Berta Casar
author_facet	Paula Colón-Bolea Rocío García-Gómez Berta Casar
author_sort	Paula Colón-Bolea
title	RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma
title_short	RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma
title_full	RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma
title_fullStr	RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma
title_full_unstemmed	RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma
title_sort	rac1 activation as a potential therapeutic option in metastatic cutaneous melanoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/51e13b68bf2940e4a3bc15a599bab654
work_keys_str_mv	AT paulacolonbolea rac1activationasapotentialtherapeuticoptioninmetastaticcutaneousmelanoma AT rociogarciagomez rac1activationasapotentialtherapeuticoptioninmetastaticcutaneousmelanoma AT bertacasar rac1activationasapotentialtherapeuticoptioninmetastaticcutaneousmelanoma
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RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma

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