Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali
Objectives: To identify the etiologies of hearing impairment (HI) in schools for students who are deaf and to use a systematic review to summarize reports on the etiologies and clinical and genetic features of HI in Mali.Methods: We included individuals with HI that started before the age of 15 year...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:51e42be6f940455789204f23eeebec8c2021-12-01T13:24:27ZEtiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali2296-236010.3389/fped.2021.726776https://doaj.org/article/51e42be6f940455789204f23eeebec8c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.726776/fullhttps://doaj.org/toc/2296-2360Objectives: To identify the etiologies of hearing impairment (HI) in schools for students who are deaf and to use a systematic review to summarize reports on the etiologies and clinical and genetic features of HI in Mali.Methods: We included individuals with HI that started before the age of 15 years old. Patients were carefully evaluated under standard practices, and pure-tone audiometry was performed where possible. We then searched for articles published on HI in the Malian population from the databases' inception to March 30, 2020.Results: A total of 117 individuals from two schools for the deaf were included, and a male predominance (sex ratio 1.3; 65/52) was noted. HI was pre-lingual in 82.2% (n = 117), and the median age at diagnosis was 12 years old. The etiologies were environmental in 59.4% (70/117), with meningitis being the leading cause (40%, 20/70), followed by cases with genetic suspicion (29.3%, 21/117). In 11.3% (8/117) of patients, no etiology was identified. Among cases with genetic suspicion, three were syndromic, including two cases of Waardenburg syndrome, while 15 individuals had non-syndromic HI. An autosomal recessive inheritance pattern was observed in 83.3% of families (15/18), and consanguinity was reported in 55.5% (10/18) of putative genetic cases.Conclusion: This study concludes that environmental factors are the leading causes of HI in Mali. However, genetic causes should be investigated, particularly in the context of a population with a high consanguinity rate.Abdoulaye YalcouyéAbdoulaye YalcouyéOumou TraoréAbdoulaye TamégaAlassane B. MaïgaFousseyni KanéOluwafemi G. OluwoleCheick Oumar GuintoCheick Oumar GuintoMohamed KéitaMohamed KéitaSamba Karim TimboSamba Karim TimboCarmen DeKockGuida LandouréGuida LandouréAmbroise WonkamAmbroise WonkamFrontiers Media S.A.articlehearing impairmentetiologygeneticsMaliAfricaPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
hearing impairment etiology genetics Mali Africa Pediatrics RJ1-570 |
| spellingShingle |
hearing impairment etiology genetics Mali Africa Pediatrics RJ1-570 Abdoulaye Yalcouyé Abdoulaye Yalcouyé Oumou Traoré Abdoulaye Taméga Alassane B. Maïga Fousseyni Kané Oluwafemi G. Oluwole Cheick Oumar Guinto Cheick Oumar Guinto Mohamed Kéita Mohamed Kéita Samba Karim Timbo Samba Karim Timbo Carmen DeKock Guida Landouré Guida Landouré Ambroise Wonkam Ambroise Wonkam Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali |
| description |
Objectives: To identify the etiologies of hearing impairment (HI) in schools for students who are deaf and to use a systematic review to summarize reports on the etiologies and clinical and genetic features of HI in Mali.Methods: We included individuals with HI that started before the age of 15 years old. Patients were carefully evaluated under standard practices, and pure-tone audiometry was performed where possible. We then searched for articles published on HI in the Malian population from the databases' inception to March 30, 2020.Results: A total of 117 individuals from two schools for the deaf were included, and a male predominance (sex ratio 1.3; 65/52) was noted. HI was pre-lingual in 82.2% (n = 117), and the median age at diagnosis was 12 years old. The etiologies were environmental in 59.4% (70/117), with meningitis being the leading cause (40%, 20/70), followed by cases with genetic suspicion (29.3%, 21/117). In 11.3% (8/117) of patients, no etiology was identified. Among cases with genetic suspicion, three were syndromic, including two cases of Waardenburg syndrome, while 15 individuals had non-syndromic HI. An autosomal recessive inheritance pattern was observed in 83.3% of families (15/18), and consanguinity was reported in 55.5% (10/18) of putative genetic cases.Conclusion: This study concludes that environmental factors are the leading causes of HI in Mali. However, genetic causes should be investigated, particularly in the context of a population with a high consanguinity rate. |
| format |
article |
| author |
Abdoulaye Yalcouyé Abdoulaye Yalcouyé Oumou Traoré Abdoulaye Taméga Alassane B. Maïga Fousseyni Kané Oluwafemi G. Oluwole Cheick Oumar Guinto Cheick Oumar Guinto Mohamed Kéita Mohamed Kéita Samba Karim Timbo Samba Karim Timbo Carmen DeKock Guida Landouré Guida Landouré Ambroise Wonkam Ambroise Wonkam |
| author_facet |
Abdoulaye Yalcouyé Abdoulaye Yalcouyé Oumou Traoré Abdoulaye Taméga Alassane B. Maïga Fousseyni Kané Oluwafemi G. Oluwole Cheick Oumar Guinto Cheick Oumar Guinto Mohamed Kéita Mohamed Kéita Samba Karim Timbo Samba Karim Timbo Carmen DeKock Guida Landouré Guida Landouré Ambroise Wonkam Ambroise Wonkam |
| author_sort |
Abdoulaye Yalcouyé |
| title |
Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali |
| title_short |
Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali |
| title_full |
Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali |
| title_fullStr |
Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali |
| title_full_unstemmed |
Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali |
| title_sort |
etiologies of childhood hearing impairment in schools for the deaf in mali |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/51e42be6f940455789204f23eeebec8c |
| work_keys_str_mv |
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