Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism

Pulmonary embolism (PE) clinical manifestations vary widely, and that scope is not fully captured by current all-cause mortality risk models. PE is associated with inflammatory, coagulation, and hemostatic imbalances so blood cellular indices may be prognostically useful. Complete blood count (CBC)...

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Autores principales:	Brett Slajus MPH, Yevgeniy Brailovsky DO, Iman Darwish BS, Jawed Fareed PhD, FAHA, Amir Darki MD, MSc
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/51e88d94ce974cf886bc3ed343d6f632
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spelling	oai:doaj.org-article:51e88d94ce974cf886bc3ed343d6f6322021-12-02T01:33:22ZUtility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism1938-272310.1177/10760296211052292https://doaj.org/article/51e88d94ce974cf886bc3ed343d6f6322021-11-01T00:00:00Zhttps://doi.org/10.1177/10760296211052292https://doaj.org/toc/1938-2723Pulmonary embolism (PE) clinical manifestations vary widely, and that scope is not fully captured by current all-cause mortality risk models. PE is associated with inflammatory, coagulation, and hemostatic imbalances so blood cellular indices may be prognostically useful. Complete blood count (CBC) data may improve current risk models like the simplified pulmonary embolism severity index (sPESI) for all-cause mortality, offering greater accuracy and analytic ability. Acute PE patients (n = 228) with confirmatory diagnostic imaging were followed for all-cause mortality. Blood cellular indices were assessed for association to all-cause mortality and were supplemented into sPESI using multivariate logistic regression. Multiple blood cellular indices were found to be significantly associated with all-cause mortality in acute PE. sPESI including red cell distribution width, hematocrit and neutrophil-lymphocyte ratio had better predictive ability as compared to sPESI alone (AUC: 0.852 vs 0.754). Blood cellular indices contribute an inflammatory and hemodynamic perspective not currently included in sPESI. CBC with differential is a widely used, low-cost test that can augment current risk stratification tools for all-cause mortality in acute PE patients.Brett Slajus MPHYevgeniy Brailovsky DOIman Darwish BSJawed Fareed PhD, FAHAAmir Darki MD, MScSAGE PublishingarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENClinical and Applied Thrombosis/Hemostasis, Vol 27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Brett Slajus MPH Yevgeniy Brailovsky DO Iman Darwish BS Jawed Fareed PhD, FAHA Amir Darki MD, MSc Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism
description	Pulmonary embolism (PE) clinical manifestations vary widely, and that scope is not fully captured by current all-cause mortality risk models. PE is associated with inflammatory, coagulation, and hemostatic imbalances so blood cellular indices may be prognostically useful. Complete blood count (CBC) data may improve current risk models like the simplified pulmonary embolism severity index (sPESI) for all-cause mortality, offering greater accuracy and analytic ability. Acute PE patients (n = 228) with confirmatory diagnostic imaging were followed for all-cause mortality. Blood cellular indices were assessed for association to all-cause mortality and were supplemented into sPESI using multivariate logistic regression. Multiple blood cellular indices were found to be significantly associated with all-cause mortality in acute PE. sPESI including red cell distribution width, hematocrit and neutrophil-lymphocyte ratio had better predictive ability as compared to sPESI alone (AUC: 0.852 vs 0.754). Blood cellular indices contribute an inflammatory and hemodynamic perspective not currently included in sPESI. CBC with differential is a widely used, low-cost test that can augment current risk stratification tools for all-cause mortality in acute PE patients.
format	article
author	Brett Slajus MPH Yevgeniy Brailovsky DO Iman Darwish BS Jawed Fareed PhD, FAHA Amir Darki MD, MSc
author_facet	Brett Slajus MPH Yevgeniy Brailovsky DO Iman Darwish BS Jawed Fareed PhD, FAHA Amir Darki MD, MSc
author_sort	Brett Slajus MPH
title	Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism
title_short	Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism
title_full	Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism
title_fullStr	Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism
title_full_unstemmed	Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism
title_sort	utility of blood cellular indices in the risk stratification of patients presenting with acute pulmonary embolism
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/51e88d94ce974cf886bc3ed343d6f632
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Utility of Blood Cellular Indices in the Risk Stratification of Patients Presenting with Acute Pulmonary Embolism

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