The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation

Abstract Carnosol is a natural compound extracted from rosemary and sage, which has been demonstrated to have anti-inflammatory, anti-oxidant, and anti-cancer properties. In this report, we evaluated the therapeutic potential and elucidated the potential mechanism of action of carnosol in chemopreve...

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Autores principales:	Lingying Tong, Shiyong Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51e936201db146c386e99b0fba358bc8
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spelling	oai:doaj.org-article:51e936201db146c386e99b0fba358bc82021-12-02T16:07:51ZThe Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation10.1038/s41598-018-22029-x2045-2322https://doaj.org/article/51e936201db146c386e99b0fba358bc82018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22029-xhttps://doaj.org/toc/2045-2322Abstract Carnosol is a natural compound extracted from rosemary and sage, which has been demonstrated to have anti-inflammatory, anti-oxidant, and anti-cancer properties. In this report, we evaluated the therapeutic potential and elucidated the potential mechanism of action of carnosol in chemoprevention of ultraviolet B-light (UVB) induced non-melanoma skin cancer formation. Our data indicated that carnosol could partially reduce UVB-induced reactive oxygen species (ROS) elevation and thus reduce DNA damage. It could also reduce UVB-induced formation of cyclobutane pyrimidine dimers (CDP) in keratinocytes possibly through its ability in absorbing UVB radiation. In addition, carnosol could inhibit the UVB-induced activation of NF-κB and also reduce UVB-induced transformation of keratinocytes. Taken together, the results indicate the role of carnosol as a potential chemopreventive agent upon UVB radiation.Lingying TongShiyong WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingying Tong Shiyong Wu The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation
description	Abstract Carnosol is a natural compound extracted from rosemary and sage, which has been demonstrated to have anti-inflammatory, anti-oxidant, and anti-cancer properties. In this report, we evaluated the therapeutic potential and elucidated the potential mechanism of action of carnosol in chemoprevention of ultraviolet B-light (UVB) induced non-melanoma skin cancer formation. Our data indicated that carnosol could partially reduce UVB-induced reactive oxygen species (ROS) elevation and thus reduce DNA damage. It could also reduce UVB-induced formation of cyclobutane pyrimidine dimers (CDP) in keratinocytes possibly through its ability in absorbing UVB radiation. In addition, carnosol could inhibit the UVB-induced activation of NF-κB and also reduce UVB-induced transformation of keratinocytes. Taken together, the results indicate the role of carnosol as a potential chemopreventive agent upon UVB radiation.
format	article
author	Lingying Tong Shiyong Wu
author_facet	Lingying Tong Shiyong Wu
author_sort	Lingying Tong
title	The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation
title_short	The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation
title_full	The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation
title_fullStr	The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation
title_full_unstemmed	The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation
title_sort	mechanisms of carnosol in chemoprevention of ultraviolet b-light-induced non-melanoma skin cancer formation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/51e936201db146c386e99b0fba358bc8
work_keys_str_mv	AT lingyingtong themechanismsofcarnosolinchemopreventionofultravioletblightinducednonmelanomaskincancerformation AT shiyongwu themechanismsofcarnosolinchemopreventionofultravioletblightinducednonmelanomaskincancerformation AT lingyingtong mechanismsofcarnosolinchemopreventionofultravioletblightinducednonmelanomaskincancerformation AT shiyongwu mechanismsofcarnosolinchemopreventionofultravioletblightinducednonmelanomaskincancerformation
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The Mechanisms of Carnosol in Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation

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