Molecular dynamics simulations of forced unbending of integrin α(v)β₃.
Integrins may undergo large conformational changes during activation, but the dynamic processes and pathways remain poorly understood. We used molecular dynamics to simulate forced unbending of a complete integrin α(v)β₃ ectodomain in both unliganded and liganded forms. Pulling the head of the integ...
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Autores principales: | Wei Chen, Jizhong Lou, Jen Hsin, Klaus Schulten, Stephen C Harvey, Cheng Zhu |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
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Materias: | |
Acceso en línea: | https://doaj.org/article/51ed0a99986c488581ef0cf316ec36c0 |
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