Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery

Abstract High expression of cluster of differentiation (CD)39 and CD73 has cardio-protective effects. We hypothesised that the expression of CD39 and CD73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing open heart surgery (OHS). The objective of this...

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Autores principales:	Chung-Sik Oh, Karam Kim, Woon-Seok Kang, Nam-Sik Woo, Po-Soon Kang, Jun-Seok Kim, Hang-Rae Kim, Seung-Hyun Lee, Seong-Hyop Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51f50a48e9894dcc84e7ccf9a4804095
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spelling	oai:doaj.org-article:51f50a48e9894dcc84e7ccf9a48040952021-12-02T15:08:04ZComparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery10.1038/s41598-018-28505-82045-2322https://doaj.org/article/51f50a48e9894dcc84e7ccf9a48040952018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28505-8https://doaj.org/toc/2045-2322Abstract High expression of cluster of differentiation (CD)39 and CD73 has cardio-protective effects. We hypothesised that the expression of CD39 and CD73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing open heart surgery (OHS). The objective of this prospective randomized trial was to compare the changes in CD39 and CD73 levels in CD4+ T cells between propofol- and sevoflurane-based anaesthesia during OHS. The study randomly allocated 156 patients undergoing OHS to a propofol or sevoflurane group. Blood was obtained preoperatively and up to 48 hours after weaning from cardiopulmonary bypass (CPB). The expression levels of CD39 and CD73 in circulating CD4+ T cells, serum cytokines and other laboratory parameters were analysed. The primary outcome was the expression of CD39 and CD73 on CD4+ T cells. Demographic data and perioperative haemodynamic changes did not show significant differences between the two groups. The expression of CD39 and CD73 in the sevoflurane group was significantly lower than in the propofol group (P < 0.001). Other laboratory findings including cardiac enzymes and cytokine levels, did not show significant intergroup differences. Propofol attenuated the decrease in CD39 and CD73 in circulating CD4+ T cells compared to sevoflurane-based anaesthesia during OHS.Chung-Sik OhKaram KimWoon-Seok KangNam-Sik WooPo-Soon KangJun-Seok KimHang-Rae KimSeung-Hyun LeeSeong-Hyop KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chung-Sik Oh Karam Kim Woon-Seok Kang Nam-Sik Woo Po-Soon Kang Jun-Seok Kim Hang-Rae Kim Seung-Hyun Lee Seong-Hyop Kim Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery
description	Abstract High expression of cluster of differentiation (CD)39 and CD73 has cardio-protective effects. We hypothesised that the expression of CD39 and CD73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing open heart surgery (OHS). The objective of this prospective randomized trial was to compare the changes in CD39 and CD73 levels in CD4+ T cells between propofol- and sevoflurane-based anaesthesia during OHS. The study randomly allocated 156 patients undergoing OHS to a propofol or sevoflurane group. Blood was obtained preoperatively and up to 48 hours after weaning from cardiopulmonary bypass (CPB). The expression levels of CD39 and CD73 in circulating CD4+ T cells, serum cytokines and other laboratory parameters were analysed. The primary outcome was the expression of CD39 and CD73 on CD4+ T cells. Demographic data and perioperative haemodynamic changes did not show significant differences between the two groups. The expression of CD39 and CD73 in the sevoflurane group was significantly lower than in the propofol group (P < 0.001). Other laboratory findings including cardiac enzymes and cytokine levels, did not show significant intergroup differences. Propofol attenuated the decrease in CD39 and CD73 in circulating CD4+ T cells compared to sevoflurane-based anaesthesia during OHS.
format	article
author	Chung-Sik Oh Karam Kim Woon-Seok Kang Nam-Sik Woo Po-Soon Kang Jun-Seok Kim Hang-Rae Kim Seung-Hyun Lee Seong-Hyop Kim
author_facet	Chung-Sik Oh Karam Kim Woon-Seok Kang Nam-Sik Woo Po-Soon Kang Jun-Seok Kim Hang-Rae Kim Seung-Hyun Lee Seong-Hyop Kim
author_sort	Chung-Sik Oh
title	Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery
title_short	Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery
title_full	Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery
title_fullStr	Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery
title_full_unstemmed	Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery
title_sort	comparison of the expression of cluster of differentiation (cd)39 and cd73 between propofol- and sevoflurane-based anaesthesia during open heart surgery
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/51f50a48e9894dcc84e7ccf9a4804095
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Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery

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