Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes

Abstract We tested the hypothesis that circulating CXCL10 and IL-6 in donor after brain death provide independent additional predictors of graft outcome. From January 1, 2010 to June 30, 2012 all donors after brain death managed by the NITp (n = 1100) were prospectively included in this study. CXCL1...

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Autores principales:	Lorenzo Piemonti, Valeria Sordi, Silvia Pellegrini, Giulia Maria Scotti, Marina Scavini, Viviana Sioli, Andrea Gianelli Castiglione, Massimo Cardillo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51f77624e49c45249399ff0145677482
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spelling	oai:doaj.org-article:51f77624e49c45249399ff01456774822021-12-02T11:45:05ZCirculating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes10.1038/s41598-021-86085-62045-2322https://doaj.org/article/51f77624e49c45249399ff01456774822021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86085-6https://doaj.org/toc/2045-2322Abstract We tested the hypothesis that circulating CXCL10 and IL-6 in donor after brain death provide independent additional predictors of graft outcome. From January 1, 2010 to June 30, 2012 all donors after brain death managed by the NITp (n = 1100) were prospectively included in this study. CXCL10 and IL-6 were measured on serum collected for the crossmatch at the beginning of the observation period. Graft outcome in recipients who received kidney (n = 1325, follow-up 4.9 years), liver (n = 815, follow-up 4.3 years) and heart (n = 272, follow-up 5 years) was evaluated. Both CXCL-10 and IL-6 showed increased concentration in donors after brain death. The intensive care unit stay, the hemodynamic instability, the cause of death, the presence of risk factors for cardiovascular disease and the presence of ongoing infection resulted as significant determinants of IL-6 and CXCL10 donor concentrations. Both cytokines resulted as independent predictors of Immediate Graft Function. Donor IL-6 or CXCL10 were associated with graft failure after liver transplant, and acted as predictors of recipient survival after kidney, liver and heart transplantation. Serum donor IL-6 and CXCL10 concentration can provide independent incremental prediction of graft outcome among recipients followed according to standard clinical practice.Lorenzo PiemontiValeria SordiSilvia PellegriniGiulia Maria ScottiMarina ScaviniViviana SioliAndrea Gianelli CastiglioneMassimo CardilloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lorenzo Piemonti Valeria Sordi Silvia Pellegrini Giulia Maria Scotti Marina Scavini Viviana Sioli Andrea Gianelli Castiglione Massimo Cardillo Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes
description	Abstract We tested the hypothesis that circulating CXCL10 and IL-6 in donor after brain death provide independent additional predictors of graft outcome. From January 1, 2010 to June 30, 2012 all donors after brain death managed by the NITp (n = 1100) were prospectively included in this study. CXCL10 and IL-6 were measured on serum collected for the crossmatch at the beginning of the observation period. Graft outcome in recipients who received kidney (n = 1325, follow-up 4.9 years), liver (n = 815, follow-up 4.3 years) and heart (n = 272, follow-up 5 years) was evaluated. Both CXCL-10 and IL-6 showed increased concentration in donors after brain death. The intensive care unit stay, the hemodynamic instability, the cause of death, the presence of risk factors for cardiovascular disease and the presence of ongoing infection resulted as significant determinants of IL-6 and CXCL10 donor concentrations. Both cytokines resulted as independent predictors of Immediate Graft Function. Donor IL-6 or CXCL10 were associated with graft failure after liver transplant, and acted as predictors of recipient survival after kidney, liver and heart transplantation. Serum donor IL-6 and CXCL10 concentration can provide independent incremental prediction of graft outcome among recipients followed according to standard clinical practice.
format	article
author	Lorenzo Piemonti Valeria Sordi Silvia Pellegrini Giulia Maria Scotti Marina Scavini Viviana Sioli Andrea Gianelli Castiglione Massimo Cardillo
author_facet	Lorenzo Piemonti Valeria Sordi Silvia Pellegrini Giulia Maria Scotti Marina Scavini Viviana Sioli Andrea Gianelli Castiglione Massimo Cardillo
author_sort	Lorenzo Piemonti
title	Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes
title_short	Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes
title_full	Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes
title_fullStr	Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes
title_full_unstemmed	Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes
title_sort	circulating cxcl10 and il-6 in solid organ donors after brain death predict graft outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/51f77624e49c45249399ff0145677482
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Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes

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