Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.

<h4>Background</h4>Japanese encephalitis (JE) is a flaviviral disease of public health concern in many parts of Asia. JE often occurs in large epidemics, has a high case-fatality ratio and, among survivors, frequently causes persistent neurological sequelae and mental disabilities. In 19...

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Autores principales:	Florian Marks, Thi Thu Yen Nguyen, Nhu Duong Tran, Minh Hong Nguyen, Hai Ha Vu, Christian G Meyer, Young Ae You, Frank Konings, Wei Liu, Thomas F Wierzba, Zhi-Yi Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/52013100c3f242fba3c69c7e7caf7bb6
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spelling	oai:doaj.org-article:52013100c3f242fba3c69c7e7caf7bb62021-11-18T09:15:33ZEffectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.1935-27271935-273510.1371/journal.pntd.0001952https://doaj.org/article/52013100c3f242fba3c69c7e7caf7bb62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272262/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Japanese encephalitis (JE) is a flaviviral disease of public health concern in many parts of Asia. JE often occurs in large epidemics, has a high case-fatality ratio and, among survivors, frequently causes persistent neurological sequelae and mental disabilities. In 1997, the Vietnamese government initiated immunization campaigns targeting all children aged 1-5 years. Three doses of a locally-produced, mouse brain-derived, inactivated JE vaccine (MBV) were given. This study aims at evaluating the effectiveness of Viet Nam's MBV.<h4>Methodology</h4>A matched case-control study was conducted in Northern Viet Nam. Cases were identified through an ongoing hospital-based surveillance. Each case was matched to four healthy controls for age, gender, and neighborhood. The vaccination history was ascertained through JE immunization logbooks maintained at local health centers.<h4>Principal findings</h4>Thirty cases and 120 controls were enrolled. The effectiveness of the JE vaccine was 92.9% [95% CI: 66.6-98.5]. Confounding effects of other risk variables were not observed.<h4>Conclusions</h4>Our results strongly suggest that the locally-produced JE-MBV given to 1-5 years old Vietnamese children was efficacious.Florian MarksThi Thu Yen NguyenNhu Duong TranMinh Hong NguyenHai Ha VuChristian G MeyerYoung Ae YouFrank KoningsWei LiuThomas F WierzbaZhi-Yi XuPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 6, Iss 12, p e1952 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Florian Marks Thi Thu Yen Nguyen Nhu Duong Tran Minh Hong Nguyen Hai Ha Vu Christian G Meyer Young Ae You Frank Konings Wei Liu Thomas F Wierzba Zhi-Yi Xu Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.
description	<h4>Background</h4>Japanese encephalitis (JE) is a flaviviral disease of public health concern in many parts of Asia. JE often occurs in large epidemics, has a high case-fatality ratio and, among survivors, frequently causes persistent neurological sequelae and mental disabilities. In 1997, the Vietnamese government initiated immunization campaigns targeting all children aged 1-5 years. Three doses of a locally-produced, mouse brain-derived, inactivated JE vaccine (MBV) were given. This study aims at evaluating the effectiveness of Viet Nam's MBV.<h4>Methodology</h4>A matched case-control study was conducted in Northern Viet Nam. Cases were identified through an ongoing hospital-based surveillance. Each case was matched to four healthy controls for age, gender, and neighborhood. The vaccination history was ascertained through JE immunization logbooks maintained at local health centers.<h4>Principal findings</h4>Thirty cases and 120 controls were enrolled. The effectiveness of the JE vaccine was 92.9% [95% CI: 66.6-98.5]. Confounding effects of other risk variables were not observed.<h4>Conclusions</h4>Our results strongly suggest that the locally-produced JE-MBV given to 1-5 years old Vietnamese children was efficacious.
format	article
author	Florian Marks Thi Thu Yen Nguyen Nhu Duong Tran Minh Hong Nguyen Hai Ha Vu Christian G Meyer Young Ae You Frank Konings Wei Liu Thomas F Wierzba Zhi-Yi Xu
author_facet	Florian Marks Thi Thu Yen Nguyen Nhu Duong Tran Minh Hong Nguyen Hai Ha Vu Christian G Meyer Young Ae You Frank Konings Wei Liu Thomas F Wierzba Zhi-Yi Xu
author_sort	Florian Marks
title	Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.
title_short	Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.
title_full	Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.
title_fullStr	Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.
title_full_unstemmed	Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.
title_sort	effectiveness of the viet nam produced, mouse brain-derived, inactivated japanese encephalitis vaccine in northern viet nam.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/52013100c3f242fba3c69c7e7caf7bb6
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Effectiveness of the Viet Nam produced, mouse brain-derived, inactivated Japanese encephalitis vaccine in Northern Viet Nam.

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