An Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods

Parvin Salehinejad,1 Mojgan Moshrefi,2,3 Touba Eslaminejad4 1Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; 2Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi Univers...

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Autores principales:	Salehinejad P, Moshrefi M, Eslaminejad T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cord blood-mscs umbilical cord-mscs amniotic fluid placenta embryonic tissues immune-rejection Cytology QH573-671
Acceso en línea:	https://doaj.org/article/5208cb91257d497797ca8cbf19882767
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spelling	oai:doaj.org-article:5208cb91257d497797ca8cbf198827672021-12-02T12:55:13ZAn Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods1178-6957https://doaj.org/article/5208cb91257d497797ca8cbf198827672020-07-01T00:00:00Zhttps://www.dovepress.com/an-overview-on-mesenchymal-stem-cells-derived-from-extraembryonic-tiss-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Parvin Salehinejad,1 Mojgan Moshrefi,2,3 Touba Eslaminejad4 1Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; 2Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 3Research and Clinical Center for Infertility, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 4Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IranCorrespondence: Touba EslaminejadKerman University of Medical Sciences, Kerman, IranTel +9834331325245Fax +9834331325215Email t_eslami@kmu.ac.irPurpose: The main aim of this review was to provide an updated comprehensive report regarding isolation methods of MSCs from human extra embryonic tissues, including cord blood, amniotic fluid, and different parts of the placenta and umbilical cord, with respect to the efficacy of these methods.Results: Extra embryonic tissues are the most available source for harvesting of mesenchymal stem cells (MSCs). They make a large number of cells accessible using non-invasive methods of isolation and the least immune-rejection reactions. A successful culture of primary cells requires obtaining a maximum yield of functional and viable cells from the tissues. In addition, there are many reports associated with their differentiation into various kinds of cells, and there are some clinical trials regarding their utilization for patients.Conclusion: Currently, cord blood-MSCs have been tested for cartilage and lung diseases. Umbilical cord-MSCs were tested for liver and neural disorders. However, these MSCs can be isolated, expanded, and cryopreserved in a cell bank for patients in need.Keywords: cord blood-MSCs, umbilical cord-MSCs, amniotic fluid, placenta, embryonic tissues, immune-rejectionSalehinejad PMoshrefi MEslaminejad TDove Medical Pressarticlecord blood-mscsumbilical cord-mscsamniotic fluidplacentaembryonic tissuesimmune-rejectionCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 13, Pp 57-65 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cord blood-mscs umbilical cord-mscs amniotic fluid placenta embryonic tissues immune-rejection Cytology QH573-671
spellingShingle	cord blood-mscs umbilical cord-mscs amniotic fluid placenta embryonic tissues immune-rejection Cytology QH573-671 Salehinejad P Moshrefi M Eslaminejad T An Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods
description	Parvin Salehinejad,1 Mojgan Moshrefi,2,3 Touba Eslaminejad4 1Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; 2Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 3Research and Clinical Center for Infertility, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 4Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IranCorrespondence: Touba EslaminejadKerman University of Medical Sciences, Kerman, IranTel +9834331325245Fax +9834331325215Email t_eslami@kmu.ac.irPurpose: The main aim of this review was to provide an updated comprehensive report regarding isolation methods of MSCs from human extra embryonic tissues, including cord blood, amniotic fluid, and different parts of the placenta and umbilical cord, with respect to the efficacy of these methods.Results: Extra embryonic tissues are the most available source for harvesting of mesenchymal stem cells (MSCs). They make a large number of cells accessible using non-invasive methods of isolation and the least immune-rejection reactions. A successful culture of primary cells requires obtaining a maximum yield of functional and viable cells from the tissues. In addition, there are many reports associated with their differentiation into various kinds of cells, and there are some clinical trials regarding their utilization for patients.Conclusion: Currently, cord blood-MSCs have been tested for cartilage and lung diseases. Umbilical cord-MSCs were tested for liver and neural disorders. However, these MSCs can be isolated, expanded, and cryopreserved in a cell bank for patients in need.Keywords: cord blood-MSCs, umbilical cord-MSCs, amniotic fluid, placenta, embryonic tissues, immune-rejection
format	article
author	Salehinejad P Moshrefi M Eslaminejad T
author_facet	Salehinejad P Moshrefi M Eslaminejad T
author_sort	Salehinejad P
title	An Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods
title_short	An Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods
title_full	An Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods
title_fullStr	An Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods
title_full_unstemmed	An Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods
title_sort	overview on mesenchymal stem cells derived from extraembryonic tissues: supplement sources and isolation methods
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5208cb91257d497797ca8cbf19882767
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An Overview on Mesenchymal Stem Cells Derived from Extraembryonic Tissues: Supplement Sources and Isolation Methods

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