Preoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer

The host’s immune system plays a crucial role in determining the clinical outcome of many cancers, including breast cancer. Peripheral blood neutrophils and lymphocytes counts may be surrogate markers of systemic inflammation and potentially reflect survival outcomes. The aim of the present study is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marta Truffi, Francesca Piccotti, Sara Albasini, Valentina Tibollo, Carlo Francesco Morasso, Federico Sottotetti, Fabio Corsi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	systemic inflammatory biomarkers early breast cancer predictive factors lymphocyte ratios disease recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/520c5dd95c2543bdb95858bfd3c846c4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:520c5dd95c2543bdb95858bfd3c846c4
record_format	dspace
spelling	oai:doaj.org-article:520c5dd95c2543bdb95858bfd3c846c42021-11-04T08:20:41ZPreoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer2234-943X10.3389/fonc.2021.773078https://doaj.org/article/520c5dd95c2543bdb95858bfd3c846c42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.773078/fullhttps://doaj.org/toc/2234-943XThe host’s immune system plays a crucial role in determining the clinical outcome of many cancers, including breast cancer. Peripheral blood neutrophils and lymphocytes counts may be surrogate markers of systemic inflammation and potentially reflect survival outcomes. The aim of the present study is to assess the role of preoperative systemic inflammatory biomarkers to predict local or distant relapse in breast cancer. In particular we investigated ER+ HER2- early breast cancer, considering its challenging risk stratification. A total of 1,763 breast cancer patients treated at tertiary referral Breast Unit were reviewed. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte (LMR) ratios were assessed from the preoperative blood counts. Multivariate analyses for 5-years locoregional recurrence-free (LRRFS), distant metastases-free (DMFS) and disease-free survivals (DFS) were performed, taking into account both blood inflammatory biomarkers and clinical-pathological variables. Low NLR and high LMR were independent predictors of longer LRRFS, DMFS and DFS, and low PLR was predictive of better LRRFS and DMFS in the study population. In 999 ER+ HER2- early breast cancers, high PLR was predictive of worse LRRFS (HR 0.42, p=0.009), while high LMR was predictive of improved LRRFS (HR 2.20, p=0.02) and DFS (HR 2.10, p=0.01). NLR was not an independent factor of 5-years survival in this patients’ subset. Inflammatory blood biomarkers and current clinical assessment of the disease were not in agreement in terms of estimate of relapse risk (K-Cohen from -0.03 to 0.02). In conclusion, preoperative lymphocyte ratios, in particular PLR and LMR, showed prognostic relevance in ER+ HER2- early breast cancer. Therefore, they may be used in risk stratification and therapy escalation/de-escalation in patients with this type of tumor.Marta TruffiFrancesca PiccottiSara AlbasiniValentina TibolloCarlo Francesco MorassoFederico SottotettiFabio CorsiFabio CorsiFrontiers Media S.A.articlesystemic inflammatory biomarkersearly breast cancerpredictive factorslymphocyte ratiosdisease recurrenceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic inflammatory biomarkers early breast cancer predictive factors lymphocyte ratios disease recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	systemic inflammatory biomarkers early breast cancer predictive factors lymphocyte ratios disease recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marta Truffi Francesca Piccotti Sara Albasini Valentina Tibollo Carlo Francesco Morasso Federico Sottotetti Fabio Corsi Fabio Corsi Preoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer
description	The host’s immune system plays a crucial role in determining the clinical outcome of many cancers, including breast cancer. Peripheral blood neutrophils and lymphocytes counts may be surrogate markers of systemic inflammation and potentially reflect survival outcomes. The aim of the present study is to assess the role of preoperative systemic inflammatory biomarkers to predict local or distant relapse in breast cancer. In particular we investigated ER+ HER2- early breast cancer, considering its challenging risk stratification. A total of 1,763 breast cancer patients treated at tertiary referral Breast Unit were reviewed. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte (LMR) ratios were assessed from the preoperative blood counts. Multivariate analyses for 5-years locoregional recurrence-free (LRRFS), distant metastases-free (DMFS) and disease-free survivals (DFS) were performed, taking into account both blood inflammatory biomarkers and clinical-pathological variables. Low NLR and high LMR were independent predictors of longer LRRFS, DMFS and DFS, and low PLR was predictive of better LRRFS and DMFS in the study population. In 999 ER+ HER2- early breast cancers, high PLR was predictive of worse LRRFS (HR 0.42, p=0.009), while high LMR was predictive of improved LRRFS (HR 2.20, p=0.02) and DFS (HR 2.10, p=0.01). NLR was not an independent factor of 5-years survival in this patients’ subset. Inflammatory blood biomarkers and current clinical assessment of the disease were not in agreement in terms of estimate of relapse risk (K-Cohen from -0.03 to 0.02). In conclusion, preoperative lymphocyte ratios, in particular PLR and LMR, showed prognostic relevance in ER+ HER2- early breast cancer. Therefore, they may be used in risk stratification and therapy escalation/de-escalation in patients with this type of tumor.
format	article
author	Marta Truffi Francesca Piccotti Sara Albasini Valentina Tibollo Carlo Francesco Morasso Federico Sottotetti Fabio Corsi Fabio Corsi
author_facet	Marta Truffi Francesca Piccotti Sara Albasini Valentina Tibollo Carlo Francesco Morasso Federico Sottotetti Fabio Corsi Fabio Corsi
author_sort	Marta Truffi
title	Preoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer
title_short	Preoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer
title_full	Preoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer
title_fullStr	Preoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer
title_full_unstemmed	Preoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer
title_sort	preoperative systemic inflammatory biomarkers are independent predictors of disease recurrence in er+ her2- early breast cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/520c5dd95c2543bdb95858bfd3c846c4
work_keys_str_mv	AT martatruffi preoperativesystemicinflammatorybiomarkersareindependentpredictorsofdiseaserecurrenceinerher2earlybreastcancer AT francescapiccotti preoperativesystemicinflammatorybiomarkersareindependentpredictorsofdiseaserecurrenceinerher2earlybreastcancer AT saraalbasini preoperativesystemicinflammatorybiomarkersareindependentpredictorsofdiseaserecurrenceinerher2earlybreastcancer AT valentinatibollo preoperativesystemicinflammatorybiomarkersareindependentpredictorsofdiseaserecurrenceinerher2earlybreastcancer AT carlofrancescomorasso preoperativesystemicinflammatorybiomarkersareindependentpredictorsofdiseaserecurrenceinerher2earlybreastcancer AT federicosottotetti preoperativesystemicinflammatorybiomarkersareindependentpredictorsofdiseaserecurrenceinerher2earlybreastcancer AT fabiocorsi preoperativesystemicinflammatorybiomarkersareindependentpredictorsofdiseaserecurrenceinerher2earlybreastcancer AT fabiocorsi preoperativesystemicinflammatorybiomarkersareindependentpredictorsofdiseaserecurrenceinerher2earlybreastcancer
_version_	1718445018240253952

Preoperative Systemic Inflammatory Biomarkers Are Independent Predictors of Disease Recurrence in ER+ HER2- Early Breast Cancer

Ejemplares similares