Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD

Abstract Urban particulate matter (UPM) is an important trigger of airway inflammation. The cross-talk between the external and internal matrix in the respiratory tract occurs due to the transepithelial network of macrophages/dendritic cells. This study characterized the immune processes induced by...

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Autores principales:	Magdalena Paplinska-Goryca, Paulina Misiukiewicz-Stepien, Malgorzata Proboszcz, Patrycja Nejman-Gryz, Katarzyna Gorska, Elwira Zajusz-Zubek, Rafal Krenke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/520f43bdd76d4d74a979cd7e6eb46128
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spelling	oai:doaj.org-article:520f43bdd76d4d74a979cd7e6eb461282021-12-02T18:02:43ZInteractions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD10.1038/s41598-021-92626-w2045-2322https://doaj.org/article/520f43bdd76d4d74a979cd7e6eb461282021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92626-whttps://doaj.org/toc/2045-2322Abstract Urban particulate matter (UPM) is an important trigger of airway inflammation. The cross-talk between the external and internal matrix in the respiratory tract occurs due to the transepithelial network of macrophages/dendritic cells. This study characterized the immune processes induced by the epithelium after UPM exposure in special regard to interactions with monocyte-derived dendritic cells (moDCs) and monocyte-derived macrophages (moMφs) in obstructive lung diseases. A triple-cell co-culture model (8 controls, 10 asthma, and 8 patients with COPD) utilized nasal epithelial cells, along with moMφs, and moDCs was exposed to UPM for 24 h. The inflammatory response of nasal epithelial cells to UPM stimulation is affected differently by cell–cell interactions in healthy people, asthma or COPD patients of which the interactions with DCs had the strongest impact on the inflammatory reaction of epithelial cells after UPM exposure. The epithelial remodeling and DCs dysfunction might accelerate the inflammation after air pollution exposure in asthma and COPD.Magdalena Paplinska-GorycaPaulina Misiukiewicz-StepienMalgorzata ProboszczPatrycja Nejman-GryzKatarzyna GorskaElwira Zajusz-ZubekRafal KrenkeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Magdalena Paplinska-Goryca Paulina Misiukiewicz-Stepien Malgorzata Proboszcz Patrycja Nejman-Gryz Katarzyna Gorska Elwira Zajusz-Zubek Rafal Krenke Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD
description	Abstract Urban particulate matter (UPM) is an important trigger of airway inflammation. The cross-talk between the external and internal matrix in the respiratory tract occurs due to the transepithelial network of macrophages/dendritic cells. This study characterized the immune processes induced by the epithelium after UPM exposure in special regard to interactions with monocyte-derived dendritic cells (moDCs) and monocyte-derived macrophages (moMφs) in obstructive lung diseases. A triple-cell co-culture model (8 controls, 10 asthma, and 8 patients with COPD) utilized nasal epithelial cells, along with moMφs, and moDCs was exposed to UPM for 24 h. The inflammatory response of nasal epithelial cells to UPM stimulation is affected differently by cell–cell interactions in healthy people, asthma or COPD patients of which the interactions with DCs had the strongest impact on the inflammatory reaction of epithelial cells after UPM exposure. The epithelial remodeling and DCs dysfunction might accelerate the inflammation after air pollution exposure in asthma and COPD.
format	article
author	Magdalena Paplinska-Goryca Paulina Misiukiewicz-Stepien Malgorzata Proboszcz Patrycja Nejman-Gryz Katarzyna Gorska Elwira Zajusz-Zubek Rafal Krenke
author_facet	Magdalena Paplinska-Goryca Paulina Misiukiewicz-Stepien Malgorzata Proboszcz Patrycja Nejman-Gryz Katarzyna Gorska Elwira Zajusz-Zubek Rafal Krenke
author_sort	Magdalena Paplinska-Goryca
title	Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD
title_short	Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD
title_full	Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD
title_fullStr	Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD
title_full_unstemmed	Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD
title_sort	interactions of nasal epithelium with macrophages and dendritic cells variously alter urban pm-induced inflammation in healthy, asthma and copd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/520f43bdd76d4d74a979cd7e6eb46128
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Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD

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