Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway

Abstract Changes in illumination can rapidly influence behavior that is normally controlled by the circadian clock. This effect is termed masking. In mice, masking requires melanopsin-expressing retinal ganglion cells that detect blue light and project to the thalamus. It is not known whether maskin...

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Autores principales: Qian Lin, Suresh Jesuthasan
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5213b7cb3e484115b2ce66593b8c4ac5
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spelling oai:doaj.org-article:5213b7cb3e484115b2ce66593b8c4ac52021-12-02T15:06:25ZMasking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway10.1038/s41598-017-04205-72045-2322https://doaj.org/article/5213b7cb3e484115b2ce66593b8c4ac52017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04205-7https://doaj.org/toc/2045-2322Abstract Changes in illumination can rapidly influence behavior that is normally controlled by the circadian clock. This effect is termed masking. In mice, masking requires melanopsin-expressing retinal ganglion cells that detect blue light and project to the thalamus. It is not known whether masking is wavelength-dependent in other vertebrates, nor is it known whether the thalamus is also involved or how it influences masking. Here, we address these questions in zebrafish. We find that diel vertical migration, a circadian behavior in larval zebrafish, is effectively triggered by blue, but not by red light. Two-photon calcium imaging reveals that a thalamic nucleus and a downstream structure, the habenula, have a sustained response to blue but not to red light. Lesioning the habenula reduces light-evoked climbing. These data suggest that the thalamo-habenula pathway is involved in the ability of blue light to influence a circadian behavior.Qian LinSuresh JesuthasanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Qian Lin
Suresh Jesuthasan
Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway
description Abstract Changes in illumination can rapidly influence behavior that is normally controlled by the circadian clock. This effect is termed masking. In mice, masking requires melanopsin-expressing retinal ganglion cells that detect blue light and project to the thalamus. It is not known whether masking is wavelength-dependent in other vertebrates, nor is it known whether the thalamus is also involved or how it influences masking. Here, we address these questions in zebrafish. We find that diel vertical migration, a circadian behavior in larval zebrafish, is effectively triggered by blue, but not by red light. Two-photon calcium imaging reveals that a thalamic nucleus and a downstream structure, the habenula, have a sustained response to blue but not to red light. Lesioning the habenula reduces light-evoked climbing. These data suggest that the thalamo-habenula pathway is involved in the ability of blue light to influence a circadian behavior.
format article
author Qian Lin
Suresh Jesuthasan
author_facet Qian Lin
Suresh Jesuthasan
author_sort Qian Lin
title Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway
title_short Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway
title_full Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway
title_fullStr Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway
title_full_unstemmed Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway
title_sort masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/5213b7cb3e484115b2ce66593b8c4ac5
work_keys_str_mv AT qianlin maskingofacircadianbehaviorinlarvalzebrafishinvolvesthethalamohabenulapathway
AT sureshjesuthasan maskingofacircadianbehaviorinlarvalzebrafishinvolvesthethalamohabenulapathway
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