CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

Help from CD4+ T cells is important to induce CD8+ T cell memory responses, but mechanistic insights are lacking. Here, the authors show, by transcriptomics and epigenetics, how CD4+ T cells help program memory CD8+ T cells for help-independent recall by antigens, as well as for innate-like recall r...

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Autores principales:	Tomasz Ahrends, Julia Busselaar, Tesa M. Severson, Nikolina Bąbała, Evert de Vries, Astrid Bovens, Lodewyk Wessels, Fred van Leeuwen, Jannie Borst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5213f8fbacb34ae3ab044b7181b1b063
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spelling	oai:doaj.org-article:5213f8fbacb34ae3ab044b7181b1b0632021-12-02T16:58:17ZCD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities10.1038/s41467-019-13438-12041-1723https://doaj.org/article/5213f8fbacb34ae3ab044b7181b1b0632019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13438-1https://doaj.org/toc/2041-1723Help from CD4+ T cells is important to induce CD8+ T cell memory responses, but mechanistic insights are lacking. Here, the authors show, by transcriptomics and epigenetics, how CD4+ T cells help program memory CD8+ T cells for help-independent recall by antigens, as well as for innate-like recall responses by IL-12/IL-18 and promoting survival by IL-15.Tomasz AhrendsJulia BusselaarTesa M. SeversonNikolina BąbałaEvert de VriesAstrid BovensLodewyk WesselsFred van LeeuwenJannie BorstNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomasz Ahrends Julia Busselaar Tesa M. Severson Nikolina Bąbała Evert de Vries Astrid Bovens Lodewyk Wessels Fred van Leeuwen Jannie Borst CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
description	Help from CD4+ T cells is important to induce CD8+ T cell memory responses, but mechanistic insights are lacking. Here, the authors show, by transcriptomics and epigenetics, how CD4+ T cells help program memory CD8+ T cells for help-independent recall by antigens, as well as for innate-like recall responses by IL-12/IL-18 and promoting survival by IL-15.
format	article
author	Tomasz Ahrends Julia Busselaar Tesa M. Severson Nikolina Bąbała Evert de Vries Astrid Bovens Lodewyk Wessels Fred van Leeuwen Jannie Borst
author_facet	Tomasz Ahrends Julia Busselaar Tesa M. Severson Nikolina Bąbała Evert de Vries Astrid Bovens Lodewyk Wessels Fred van Leeuwen Jannie Borst
author_sort	Tomasz Ahrends
title	CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
title_short	CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
title_full	CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
title_fullStr	CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
title_full_unstemmed	CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
title_sort	cd4+ t cell help creates memory cd8+ t cells with innate and help-independent recall capacities
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5213f8fbacb34ae3ab044b7181b1b063
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CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

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