Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to find CP-mediated, spike/nucleocapsid-focused modulat...

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Autores principales: Jonathan D. Herman, Chuangqi Wang, Carolin Loos, Hyunah Yoon, Johanna Rivera, M. Eugenia Dieterle, Denise Haslwanter, Rohit K. Jangra, Robert H. Bortz, Katharine J. Bar, Boris Julg, Kartik Chandran, Douglas Lauffenburger, Liise-anne Pirofski, Galit Alter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/5214fb7ba9d240e5bff4799c7e668657
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Sumario:Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to find CP-mediated, spike/nucleocapsid-focused modulations of humoral responses in the recipient.

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