Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response
Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to find CP-mediated, spike/nucleocapsid-focused modulat...
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Nature Portfolio
2021
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oai:doaj.org-article:5214fb7ba9d240e5bff4799c7e6686572021-11-28T12:32:16ZFunctional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response10.1038/s41467-021-27201-y2041-1723https://doaj.org/article/5214fb7ba9d240e5bff4799c7e6686572021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27201-yhttps://doaj.org/toc/2041-1723Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to find CP-mediated, spike/nucleocapsid-focused modulations of humoral responses in the recipient.Jonathan D. HermanChuangqi WangCarolin LoosHyunah YoonJohanna RiveraM. Eugenia DieterleDenise HaslwanterRohit K. JangraRobert H. BortzKatharine J. BarBoris JulgKartik ChandranDouglas LauffenburgerLiise-anne PirofskiGalit AlterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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DOAJ |
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| language |
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| topic |
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Science Q Jonathan D. Herman Chuangqi Wang Carolin Loos Hyunah Yoon Johanna Rivera M. Eugenia Dieterle Denise Haslwanter Rohit K. Jangra Robert H. Bortz Katharine J. Bar Boris Julg Kartik Chandran Douglas Lauffenburger Liise-anne Pirofski Galit Alter Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response |
| description |
Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to find CP-mediated, spike/nucleocapsid-focused modulations of humoral responses in the recipient. |
| format |
article |
| author |
Jonathan D. Herman Chuangqi Wang Carolin Loos Hyunah Yoon Johanna Rivera M. Eugenia Dieterle Denise Haslwanter Rohit K. Jangra Robert H. Bortz Katharine J. Bar Boris Julg Kartik Chandran Douglas Lauffenburger Liise-anne Pirofski Galit Alter |
| author_facet |
Jonathan D. Herman Chuangqi Wang Carolin Loos Hyunah Yoon Johanna Rivera M. Eugenia Dieterle Denise Haslwanter Rohit K. Jangra Robert H. Bortz Katharine J. Bar Boris Julg Kartik Chandran Douglas Lauffenburger Liise-anne Pirofski Galit Alter |
| author_sort |
Jonathan D. Herman |
| title |
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response |
| title_short |
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response |
| title_full |
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response |
| title_fullStr |
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response |
| title_full_unstemmed |
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response |
| title_sort |
functional convalescent plasma antibodies and pre-infusion titers shape the early severe covid-19 immune response |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5214fb7ba9d240e5bff4799c7e668657 |
| work_keys_str_mv |
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